Paclitaxel mushonga wakakosha unoshandiswa zvakanyanya mukurapa cancer, asi masosi ayo ane mashoma.Kuti zvizadzise kudiwa kwepaclitaxel mumusika wemishonga, masayendisiti akaita tsvakiridzo yakakura, nesemi-synthetic nzira dzichiva nzira yakakosha yekugadzira.Ichi chinyorwa chichasuma maitiro e semi-synthesizing paclitaxel kubva ku10-deacetylbaccatin III (10-DAB) uye kusimbisa kukosha kwayo mumunda wekugadzirwa kwezvinodhaka.
Paclitaxel, yakatanga yakaparadzaniswa kubva pamakwati emuti wePacific yew, inozivikanwa nekuda kwemaitiro ayo ekurwisa cancer.Nekudaro, iyo Pacific yew inzvimbo inogumira yechisikigo, haina kukwana kuzadzisa kudiwa kwemazuva ano kwekurapa kwepaclitaxel.Kugadzirwa kwesemi-synthetic nzira kwaita kuti kugadzirwa kwakakura kwepaclitaxel kugoneke, ne10-deacetylbaccatin III iri yepakati yakakosha.
Kugadzirira kwe10-DAB muSemi-Synthetic Paclitaxel:
10-DAB yakakosha yepakati munzira yesemi-synthetic kuenda paclitaxel uye inoda matanho akati wandei ekugadzirira kwayo.Kazhinji, kuumbwa kwe10-DAB kunotanga neinotangira paclitaxel, taxuyunnanine C, inotorwa kubva ku baccatin III.Baccatin III inotanga deacetylated kuti ibudise 10-deacetylbaccatin III.Zvadaro, 10-deacetylbaccatin III inopinda maitiro akawanda, kusanganisira hydrogenation, substitution, epoxidation, hydrolysis, uye nezvimwe, pakupedzisira kuchinja kuva 10-DAB.
Zvishandiso zve10-DAB muSemi-Synthetic Paclitaxel:
Iyo synthesis yegumi-DAB yakavhura nzira nyowani yeiyo semi-synthesis ye paclitaxel, ichipa kusimudzira mukugadzirwa kwezvinodhaka.Paclitaxel mushonga wakakura-spectrum anticancer unoshandiswa kurapa marudzi akasiyana egomarara, anosanganisira ovarian, zamu, nekenza yemapapu.Iyo semi-synthetic nzira inoderedza mutengo wekugadzira zvinodhaka, zvichiita kuti iyi yakakosha kurapwa sarudzo iwanikwe kune varwere.
Mhedziso:
Iyo nzira ye semi-synthesizing paclitaxel kubva ku10-DAB yakawana budiriro yakakosha mumunda wekugadzira zvinodhaka.Iyo haingogadzirise chete nyaya yeashoma masosi masosi epaclitaxel asi zvakare inosimudzira kugadzirwa kwakanaka uye kusimba.Iyi tekinoroji inomiririra chiitiko chakakosha mukugadzirwa kwemishonga yekurwisa cancer uye ine chivimbiso chekuenderera mberi mune zvekurapa kurwisa zvirwere zvakakomba segomarara.Mune ramangwana, vatsvakurudzi vacharamba vachinatsa nzira dzekubatanidza kuvandudza kushanda uye kuderedza mari, pakupedzisira vachibatsira huwandu hwakawanda hwevarwere.
Ongorora: Zvingango batsira uye mashandisirwo ataurwa munyaya ino anobva pamabhuku anowanika pachena.
Kuwedzera Kuverenga: Yunnan Hande Biotech Co., Ltd., ine makore makumi maviri nematanhatu ekutarisa paclitaxel kugadzirwa, inogadzira yakazvimiririra pasi rose yemiti-yakabviswa anticancer drug paclitaxel inoshanda mishonga yemishonga, inotenderwa nemasangano anodzora seUS FDA, European EDQM. , Australia TGA, China CFDA, India, Japan, nevamwe.Yunnan Hande Paclitaxel, inowanikwa mustock, inotengeswa zvakananga nemugadziri.Ndapota inzwa wakasununguka kufonera kubvunza pa +86 18187887160 (WhatsApp).
Nguva yekutumira: Oct-24-2023