Paclitaxel, musanganiswa wechisikigo unobva pamuti weYew, wave uchichinja-chinja mukurapa kenza kwemakumi emakore.Zvisinei, kuwanikwa kushoma uye kudhura kwakanyanya kwekubvisa paclitaxel kubva mumiti yeyew kwakaita kuti masayendisiti agadzire dzimwe nzira.Kuuya kwe10- deacetylbaccatin III(10-DAB)semi-synthetic paclitaxel API,hupfu chena yakabva kune zvinogadzirwazve zvirimwa,yakavhura mikana mitsva mumunda we oncology.Chinyorwa ichi chinoongorora kugona kweiyi semi-synthetic API uye kukanganisa kwayo pagomarara. kurapwa.
Kuwedzera Kuwanikwa uye Kugara:
Iyo synthesis ye paclitaxel kubva10-DABinopa mhinduro yakagadzikana kune zvisingakwanisi yew tree extraction.Nzira dzechinyakare dzakakohwewa paclitaxel kubva muyew bark, zvichikonzera kushushikana kwezvakatipoteredza uye kurambidzwa kupa.Mukupesana, iyo semi-synthetic process inoshandisa 10-DAB inobvumira kugadzirwa kwakakura, kuve nechokwadi kugadzikana. uye kupihwa kwakasimba kwemushonga uyu unokosha.Kubudirira uku hakungotaridzi kushushikana kwezvakatipoteredza chete asiwo kunowedzera kuwanikwa kwepaclitaxel kune varwere pasi rese.
Kuvandudza Mutengo-Kushanda:
Kubudirira kwe10-DAB semi-synthetic paclitaxel APIine mukana wekuderedza mutengo wekurapwa kwegomarara zvakanyanya.Kuwanda uye kubudirira kwemaitiro ekugadzira kunobatsira kuti pave nemushonga usingadhuri uye unokwanisa kuwanikwa, kurerutsa mutoro wezvemari kuvarwere nehurongwa hwekuchengetedza hutano. marapirwo anoponesa hupenyu, pakupedzisira anovandudza mhedzisiro uye huwandu hwekupona.
Kuwedzerwa Kurapa Kwekushandisa:
Kupfuura basa rayo rakagadzwa mukurapa kenza yemazamu, ovarian, uye yemapapu,10-DAB semi-synthetic paclitaxel APIinopa mikana inofadza yekuongorora mishonga mitsva yekurapa.Vatsvakurudzi vanogona kuongorora kushanda kwayo mumhando dzakasiyana-siyana dzegomarara, zvichida kuwedzera mashandisirwo ayo kusvika kuzvirwere zvisingarapiki zvaimborapika.Uyezve, musanganiswa we10-DAB paclitaxel nemamwe maanti-gomarara anogona kupa mhedzisiro, kuwedzera kurapwa. migumisiro uye kuderedza kuramba zvinodhaka.
Mushonga Wakasarudzika uye Precision Oncology:
Nekuwanikwa kwe10-DAB semi-synthetic paclitaxel API, mushonga wakasarudzika uye chaiyo oncology inogona kufambiswa mberi. Nekugadzirisa marapirwo ekurapa kune mumwe nemumwe murwere zvichienderana nemajini avo, hunhu hwechirwere, uye mhinduro yekurapa, nyanzvi dzehutano dzinogona kugonesa mhedzisiro yekurapa nepo. kuderedza migumisiro yechirwere.Kusiyana-siyana kwe10-DAB paclitaxel API inobvumira nzira dzokurapa dzakagadzirirwa, kupa varapi simba kuti vape marapirwo anonangwa ane hunyanzvi hwakavandudzwa.
Mhedziso:
Nhanganyaya ye10-DAB semi-synthetic paclitaxel APIinoratidza chiitiko chakakosha mumunda wekurapa cancer.Ihu hupfu chena hunopa kuwanikwa kwakawedzerwa, kusimba, uye kudhura-zvinoita, kushandura kuwanika kwepaclitaxel.Nekuwedzera kwayo kwekurapa kwekushandisa uye kugona kwemishonga yemunhu, 10-DAB paclitaxel API ine vimbiso huru. mukushandura mamiriro ekuchengetedza cancer.As research and development in this area inoenderera mberi,ramangwana rekurapwa kwegomarara rinopenya nekugona kunobatsira kweichi tsvakiridzo inoshamisa.
Nguva yekutumira: May-17-2023