Paclitaxel inokosha anticancer mushonga, uye chimiro chayo chakasiyana uye chiitiko chebhayoloji chakwezva kutarisisa kubva kune vesainzi. Maererano nekwairi uye nzira yekugadzirira, paclitaxel inogona kupatsanurwa kuita natural paclitaxel uye semi-synthetic paclitaxel.Chinyorwa ichi chichakurukura kusiyana uye zvakanakira yevaviri.
Kunobva uye nzira yekugadzirira
Natural paclitaxel:Natural paclitaxel inonyanya kutorwa kubva muPacific yew tree(Taxus brevifolia).Muti uyu wakapfuma mu paclitaxel,asi muhuwandu hushoma,zvinoita kuti kuwanikwa kwepaclitaxel kwave kushomeka.
Semi-synthetic paclitaxel:Semi-synthetic paclitaxel inogadzirwa nemakemikari synthesis kubva kune taxanes yakatorwa kubva pabark ye taxus chinensis.Iyi nzira inogona kushandiswa kubudisa paclitaxel pamwero mukuru kuti uwane zvinodiwa nekliniki.
Chimiro chemakemikari
Kunyangwe natural paclitaxel uye semi-synthetic paclitaxel zvichisiyana zvishoma muchimiro chemakemikari, chimiro chazvo chepakati chakafanana, uye ese ari diterpenoid alkaloids.
Biological chiitiko uye efficacy
Natural paclitaxel:Mukuita kwekiriniki, paclitaxel yechisikigo yakaratidzwa kuva nerapo yakakosha pamhando dzakasiyana dzekenza, kusanganisira kenza yemazamu, kenza yeovarian, imwe kenza yemusoro nemutsipa, uye kenza yemapapu. ye tubulin uye kuparadza sero microtubule network, nekudaro ichivharira kuwanda kwesero uye kukonzeresa apoptosis yekenza maseru.
Semi-synthetic paclitaxel:Semi-synthetic paclitaxel yakafanana mukushanda kune yakasikwa paclitaxel uye zvakare ine yakakosha anticancer chiitiko.Kugadzirwa kwakawanda kwesemi-synthetic paclitaxel kunogona kuwedzera kuwanikwa kwekiriniki uye kupa mamwe maitiro ekurapa kune varwere vekenza.
Toxic side effects
Natural paclitaxel:Kutyisa kwepaclitaxel yechisikigo kwakadzikira, asi kunogona kukonzera mamwe maitiro akashata, senge allergic reaction, kudzvinyirirwa kwemwongo uye huturu hwemoyo.
Semi-synthetic paclitaxel:Migumisiro ye semi-synthetic paclitaxel yakafanana neyepaclitaxel yepanyama.Zvose zvinoda mishonga inonzwisisika inoenderana nemamiriro ezvinhu ega uye mazano echiremba kuderedza dambudziko rekuita kwakashata.
Tarisiro yebudiriro yeramangwana
Nekuenderera mberi kwekuenderera mberi kwesainzi uye tekinoroji, tsvagiridzo yepaclitaxel iri kuwedzera zvakare. Mune ramangwana, masayendisiti achashanda kutsvaga nzira dzakasimba dzepaclitaxel synthesis kuti iwedzere kukwirisa maitiro ayo ekugadzira uye kuvandudza kushanda kwekiriniki. kuvandudzwa kwehunyanzvi huri kusimukira senge genetic engineering uye cell therapy, nzira dzekurapa dzepaclitaxel zvinogoneka, nekudaro kupa varwere vegomarara nzira dzekurapa dzakanyatso uye dzinoshanda.
Mhedziso
Zvosenatural paclitaxeluyesemi-synthetic paclitaxelvane basa rinokosha rekurwisa kenza mumakiriniki maitiro.Kunyangwe mavambo avo uye nzira dzekugadzirira dzakasiyana, vanogovana zvakafanana muchimiro chemakemikari, biological chiitiko uye pharmacodynamics.Kugadzirwa kwakakura kwesemi-synthetic paclitaxel kunogona kuwedzera kuwanikwa kwekiriniki, nepo paclitaxel yepanyama ine Muzvidzidzo zvenguva yemberi, masayendisiti acharamba achiongorora nzira dzehupenyu hwekuita uye nzvimbo dzekushandisa dzepaclitaxel kuunza tariro yekurapa kune varwere vekenza.
Ongorora: Mabhenefiti angangodaro uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akaburitswa.
Nguva yekutumira: Nov-29-2023