Paclitaxel, mushonga wechisikigo anticancer ine formula C47H51NO14, yakashandiswa zvakanyanya mukurapa kenza yemazamu, ovarian cancer uye mamwe musoro, mutsipa nemapapu.Se diterpenoid alkaloid ine anticancer chiitiko,paclitaxelyakafarirwa zvikuru neve botanist, chemist, pharmacologists uye molecular biologist nekuda kweinoveli uye yakaoma makemikari chimiro, yakakura uye yakakosha biological chiitiko, nyowani uye yakasarudzika nzira yekuita, uye kushomeka zviwanikwa, zvichiita kuti ive nyeredzi uye yekutsvagisa kutarisisa kweanticancer mu chikamu chechipiri chezana remakore rechi20.
Mechanism yekuita paclitaxel
Paclitaxel inhibits kuwanda kwemasero egomarara kunyanya nekukonzeresa kusungwa kwesero kutenderera uye kukonzera njodzi mitotic.Rinovhero rayo uye yakaoma chimiro chemakemikari inoipa yakasarudzika biological maitiro ekuita.Paclitaxelinogona kudzivisa kupararira kwesero nekudzivisa polymerization ye tubulin uye kuparadza cell microtubule network.Pamusoro pezvo, paclitaxel inogona zvakare kukurudzira kutaura kwevamiriri vepro-apoptotic uye kugadzirisa basa revanorwisa-apoptotic mediators, nekudaro vachikurudzira apoptosis yekenza maseru.
Anti-gomarara basa repaclitaxel
Paclitaxel yakakwezva kutarisisa nekuda kwekushanda kwayo kwakanyanya uye kuderera kwehupfu hwekuita kweanticancer.Mukuita zvekiriniki, paclitaxel yakaratidzwa kuve neakakosha kurapa mhedzisiro pamhando dzakasiyana dzegomarara, kusanganisira kenza yemazamu, kenza yeovarian, imwe kenza yemumusoro nemutsipa, uye kenza yemapapu.Kuburikidza neyakasiyana mashandiro ehupenyu, paclitaxel inogona kunyatso kuvharidzira kuwanda kwekenza maseru uye kukurudzira apoptosis yekenza maseru.Uye zvakare, iyo anti-cancer chiitiko che paclitaxel ine hukama zvakare nekugona kwayo kudzora maitiro ekudzivirira ezvirwere zvebundu maseru.
Resource kushomeka kwe paclitaxel
Kunyangwe paclitaxel ine yakakosha anticancer chiitiko, kushomeka kwayo kwekushandisa kwakaganhurira kushandiswa kwayo kwekiriniki kwakapararira.Paclitaxel inonyanya kutorwa kubva kuPacific yew miti, uye nekuda kwekushomeka zviwanikwa, kugadzirwa kwepaclitaxel kuri kure nekusangana nezvinodiwa zvekiriniki.Nokudaro, kutsvaga kwezvitsva zvepaclitaxel, zvakadai sekugadzirwa kwepaclitaxel ne biosynthesis kana kemikari synthesis, ndiyo inotarisa pakutsvakurudza kwemazuva ano.
mhedziso
Semushonga wechisikigo anticancer,paclitaxeline hunhu hwepamusoro-soro, yakaderera muchetura uye yakafara spectrum, uye yakasarudzika biological maitiro ekuita uye yakakosha anticancer chiitiko chinoita kuti ive yakakosha kurapwa kenza mushonga mukurapwa kwekiriniki.Nekudaro, nekuda kwekushomeka kwezviwanikwa zvayo, kushandiswa kwayo kwakakura mukuita kwekiriniki kunogumira.Naizvozvo, tsvakiridzo yeramangwana inofanira kutarisa pakutsvaga zvitsva zvepaclitaxel kuti isangane nezvido zvekiriniki uye nekupa dzimwe nzira dzekurapa dzevarwere vegomarara.
Ongorora: Mabhenefiti angangoitwa uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akadhindwa.
Nguva yekutumira: Nov-24-2023