Paclitaxel chinhu chakatorwa kubva muyew, chinogona kuvharisa cancer uye chinoshandiswa zvakanyanya pasi rose. Mumakore ekuma1960, maAmerican chemist akaparadzanisa taxol kubva pamakwati ePacific yew, chirimwa cheTaxus. Mushure memakore anopfuura makumi maviri tsvakiridzo yekiriniki, jekiseni rekutanga repaclitaxel "Taxol" rakatangwa muna 1992.paclitaxelndeimwe yemishonga inozivikanwa yebotanical anti-bundu inoshanda zvakanaka.Iine hunhu hwepamusoro-soro,hupfu hushoma uye huzhinji hwakakura.Iine kurapa kuri pachena kwegomarara reovarian,gomarara rezamu,rakaipa Melanoma,gomarara remapapu,kenza yeprostate,uropi. cancer uye colorectal cancer.
Migumisiro yekuedza kwezvokurapa inoratidza kuti, ikozvino, kutorwa kwepaclitaxel APIszvinonyanya zvinoenderana nekubviswa kweTaxus chinensis zvirimwa uye makemikari Semisynthesis.Vaongorori veSainzi vanounganidza matavi akarimwa nemashizha eTaxus chinensis chinensis, shandisa solvent extraction,solid phase extraction,Supercritical fluid extraction,membrane separation,chromatographic separation uye dzimwe nzira dzekuparadzanisa uye dzekubvisa. bvisa maprecursors akafanana nechimiro che paclitaxel, senge bacatine III, 10 deacetyl bacatine III, zvichingodaro, uye wobva watora mishonga yekurapa paclitaxel yakawanda nekugadziriswa kwekemikari yemaitiro ekugadzira akawanda.
Zvinoenderana nekuverenga kwesainzi, varwere vegomarara vanofanirwa kudya zvinopfuura magiramu maviri epaclitaxelmune imwe nzira yekurapa.Izvi zvinyorwa zvepaclitaxel zvinoda kutorwa kubva pamakwati emiti yeTaxus chinensis 4-8 iyo yakakura kwemakore anopfuura 50. Kune rumwe rutivi, Taxus chinensis uye paclitaxel zvishoma, uye pane nerumwe rutivi, kune kudiwa kukuru kwekurapa, izvo zvinotungamira kumutengo wepamusoro weTaxus chinensis zvigadzirwa gore rose, uye kuwanikwa kunotadza kudiwa.
Tsanangudzo:Kugona kuita uye mashandisirwo ataurwa muchinyorwa chino zvese zvinobva mumabhuku anowanikwa pachena.
Kuwedzera kuverenga:Yunnan Hande Bio-tech inonyanya kuita basa rekubvisa nekusimudzira taxanes.Zvigadzirwa zvayo zvepakati ndezvakasikwa Paclitaxel,10-DAB Semisynthesis Paclitaxel,10-DABIII,docetaxel,cabataxel,etc.Kana uchida kuziva nezve paclitaxel based raw materials, ndapota inzwa wakasununguka kutibata pa.
Nguva yekutumira: Jun-14-2023