Paclitaxel mushonga unoitika pachisikigo une basa rakakosha rekurwisa cancer, rinoshandiswa zvakanyanya mukurapa kenza dzakasiyana siyana.Nekuwedzera kuri kuita kudiwa kwekiriniki, maitiro ekugadzira uye tekinoroji.Purogiramu inonzi Paclitaxelvari zvakare kuenderera mberi vachigadzira.Chinyorwa ichi chichasuma maitiro ekugadzira uye tekinoroji yePaclitaxel API zvakadzama.
I.Source uye Kutorwa kwePaclitaxel
Paclitaxel inonyanya kutorwa kubva kuTaxus brevifolia,Taxus cuspidata,Taxus wallichiana nemamwe marudzi eTaxus.Nzira dzekuchera dzinonyanya kusanganisira kunyungudutswa kwesolvent,ultrasonic extraction,microwave extraction,etc.Solvent extraction inowanzoshandiswa nzira,asi ine matambudziko akadai senguva yakareba yekubvisa. uye kushandiswa kukuru kwezvinonyungudutsa.Naizvozvo, mumakore achangopfuura, vatsvakurudzi vave vachiramba vachiedza nzira itsva dzekuchera, dzakadai se enzyme hydrolysis, supercritical fluid extraction, nezvimwewo, kuvandudza kushanda zvakanaka uye kuchena.
II.Kugadzira Maitiro ePaclitaxel
Fermentation nzira yekugadzira Paclitaxel
Mumakore achangopfuura, nzira dzekuvirisa dzakadzidzwa zvakanyanya pakugadzirwa kwePaclitaxel.Iyi nzira inoshandisa tekinoroji yekuvirisa hutachiona kuburitsa Paclitaxel nekurima nekuvirisa maTaxus cell.Nzira iyi ine zvakanakira senge kupfupika kwekugadzira, goho repamusoro, uye kuchena kwakanyanya.Zvisinei. , inoda optimization yemamiriro ekuvirisa uye kutariswa kwemhando-inopa goho repamusoro kuvandudza kushanda kwekugadzira uye kuderedza mitengo.
Chemical synthesis nzira yekugadzira Paclitaxel
Chemical synthesis ndiyo imwe nzira yakakosha yekugadzirwa kwePaclitaxel.Iyi nzira inoshandisa organic synthesis tekinoroji kugadzira Paclitaxel kuburikidza nemakemikari synthesis nzira.Kunyangwe nzira iyi ine zvakanakira senge kugadzirwa kwakakura uye kuchena kwakanyanya, ine zvipingamupinyi zvakaita senzira refu dzekugadzira uye mitengo yakakwira, inoganhura kushandiswa kwayo kunoshanda.
Musanganiswa wekutorwa kwechisikigo uye makemikari synthesis mukugadzira maitiro
Kuti vakunde zvipingamupinyi zvenzira imwe chete yekugadzira, vatsvakurudzi vari kuongororawo musanganiswa wekutorwa kwechisikigo uye makemikari synthesis mukugadzirwa kwekugadzira.Iyi nzira inotanga inobvisa precursor zvinhu zvePaclitaxel kubva kumhando dzeTaxus vachishandisa kunyungudutsa, uye vozoshandura kuita Paclitaxel vachishandisa kemikari synthesis. tekinoroji.Iyi nzira inosanganisa zvakanakira kudhirowa kwechisikigo uye makemikari synthesis, inovandudza kugadzira uye kuchena, uye inoderedza mutengo wekugadzira.
III.Matambudziko uye Mafambiro Ekuvandudza muPaclitaxel Production Technology
Kuvandudza kudhirowa uye kuchena: Kugadzira nzira dzakasimba uye dzakatipoteredza dzekubvisa uye matekinoroji, senge masolvents matsva, ma enzymes anoumbwa, nezvimwewo, kuvandudza kudhirowa uye kuchena kwePaclitaxel.
Kunatsiridza mamiriro ekuvirisa uye kuongorora madhiri anobereka zvakanyanya:Kunatsiridza mamiriro ekuvirisa (senge yepakati kuumbwa, tembiricha, pH kukosha, zvichingodaro) uye kuongorora madhiri anobereka zvakanyanya kuwedzera goho uye kuchena kwekuvirisa-kwakavakirwa Paclitaxel kugadzirwa.
Kuderedza mitengo yekugadzira: Kugadzira zviwanikwa zvitsva, kuvandudza maitiro ekugadzira, uye kuwana kugadzirwa kwakakura kudzikisa mutengo wekugadzira wePaclitaxel uye kuvandudza kukwikwidza kwayo kwemusika.
Kusimbisa hutongi hwemhando: Kumisikidza yakazara yemhando yekudzora sisitimu kuti inyatso kudzora mhando yezvakagadzirwa, maitiro ekugadzira, uye zvigadzirwa kuburikidza nekuomarara kwehutongi hwemhando uye ongororo yekuongorora kuve nechokwadi chemhando yechigadzirwa uye kuchengetedzeka.
Kugadzira maumbirwo matsva:Kugadzira maumbirwo matsva (akadai senananomaterials, liposome formulations, nezvimwewo) kuvandudza bioavailability uye kushanda nesimba kwePaclitaxel in vivo zvichienderana nekukanganisa kwayo kwekiriniki yekushandisa.
Kuwedzera minda yekushandisa: Kuwedzera kuwedzera minda yekushandisa yePaclitaxel kupfuura kurapwa kwegomarara (senge anti-kuzvimba, antioxidant mhedzisiro), kuti iite yakakura kwazvo pharmacological mhedzisiro uye kukosha kwekushandisa.
IV. Mhedziso uye Zvinotarisirwa
Nekuenderera mberi kwekufambira mberi kwesainzi uye tekinoroji uye kuwedzera kwekiriniki kudiwa kwePurogiramu inonzi Paclitaxel, maitiro ekugadzira uye tekinoroji yePaclitaxel API iri kuramba ichivandudza.Mune ramangwana, vaongorori vacharamba vachiongorora maitiro matsva ekugadzira uye tekinoroji nzira dzekuvandudza kugadzirwa kwePaclitaxel, kuderedza mutengo wekugadzira, kuwedzera minda yayo yekushandisa, uye kupa mipiro yakakura. kuhutano hwevanhu.
Ongorora: Iko kugona kushanda uye mashandisirwo ataurwa muchinyorwa chino anotorwa kubva kumabhuku akaburitswa pachena.
Nguva yekutumira: Zvita-13-2023