Paclitaxel musanganiswa wechisikigo wakatorwa kubva mumuti weyew, une basa rakakosha rekurwisa bundu. Sezvo paclitaxel yakatanga kuparadzaniswa kubva kumakwati ePacific yew muna 1971, tsvakiridzo yayo mundima yekurapa cancer yave inonakidza. ongorora zvakadzama maitiro ekurapa kwepaclitaxelpamhando dzakasiyana dzegomarara.
Chimiro uye zvivakwa zve paclitaxel
Paclitaxel is a complex tetracyclic diterpenoid compound ine unique three-dimensional structure, iyo inopa hwaro hwekuita kwayo anti-bundu.Its molecular formula is C47H51NO14, molecular weight is 807.9, uye ilight yellow crystalline poda patembiricha yekamuri.
Anti-gomarara nzira yepaclitaxel
Iyo anti-cancer mechanism ye paclitaxel inonyanya kuenderana nekudzivirirwa kwayo kwetubulin depolymerization uye mhedzisiro yayo pakupatsanurwa kwesero uye kupararira.Kunyanya, paclitaxel inogona kukurudzira microtubule polymerization uye inhibit microtubule depolymerization, nokudaro ichikanganisa nzira yakajairika yekuparadzaniswa kwesero uye kupararira, zvichitungamira. Uye zvakare, paclitaxel inogona zvakare kukurudzira cell apoptosis uye inhibit tumor angiogenesis.
Kurapa kwepaclitaxel pamhando dzakasiyana dzegomarara
1.Kenza yemazamu:Kurapa kwepaclitaxel pagomarara rezamu kwave kuzivikanwa zvakanyanya.Muongororo yevarwere makumi mana nevashanu vegomarara rezamu,paclitaxel yakasanganiswa nechemotherapy yakakonzera kuderera kwebundu mu41% yevarwere uye kurarama kweinopfuura mwedzi makumi maviri.
2.Non-small cell lung cancer:Kune isiri diki cell cancer yemapapu,paclitaxel yakasanganiswa neplatinum-based chemotherapy drugs inogona kuvandudza zvakanyanya kurarama kwevarwere.Ongororo yevarwere makumi matatu nevatanhatu vane isiri diki kenza yemapapu yakaratidza kuti paclitaxel yakasanganiswa chemotherapy yakaguma nekupona kwepakati kwemwedzi ye12.
3. Kenza yeOvarian: Mukurapwa kwevarwere vekenza yemaovarian makumi manomwe, paclitaxel yakasanganiswa neplatinum-based chemotherapy drugs yakaderedza mapundu mu76% yevarwere, uye makore maviri ekupona akasvika 38%.
4. Gomarara resophageal: Mukurapwa kwevarwere makumi mana vane gomarara resophageal, paclitaxel yakasanganiswa neradiotherapy yakaderedza mapundu mu85% yevarwere, uye mwero wegore rimwe wekupona wakasvika 70%.
5.Gastric cancer:Mukurapa cancer yemudumbu,paclitaxel yakasanganiswa nefluorouracil inogona kuvandudza zvakanyanya kupona kwevarwere.Muchidzidzo chevarwere makumi mashanu vane cancer yemudumbu,paclitaxelyakasanganiswa nekemotherapy yakaguma nekupona kwepakati kwemwedzi ye15.
6.Colorectal cancer:Mukurapwa kwevarwere makumi matatu vane cancer colorectal,paclitaxel yakasanganiswa neoxaliplatin yakaderedza mapundu mu80% yevarwere, uye makore maviri ekupona akasvika makumi mana%.
7.Chiropa kenza:Kunyangwe mhedzisiro yepaclitaxel monotherapy pagomarara rechiropa ishoma, kusanganiswa kwemamwe chemotherapy mishonga senge cisplatin uye 5-fluorouracil kunogona kuvandudza zvakanyanya kupona kwevarwere.Ongororo yevarwere makumi mana vane cancer yechiropa yakaratidza kuti paclitaxel yakasanganiswa. nekemotherapy yakaguma nekupona kwepakati kwemwedzi ye9.
8.Kenza yeitsvo:Pakurapwa kwegomarara reitsvo,paclitaxel yakasanganiswa nemishonga inodzivirira zvirwere zvakaita se interferon-alpha inogona kuvandudza zvikuru kurarama kwevarwere.Ongororo yakaitwa pavarwere makumi mashanu vane kenza yeitsvo yakaratidza kuti paclitaxel yakasanganiswa ne immunotherapy yakaita kuti vanhu vararame zviri pakati nepakati. 24 mwedzi.
9.Leukemia:Mukurapa kweacute myeloid leukemia,paclitaxel yakasanganiswa nemishonga yemakemotherapy yakadai secytarabine inogona kuita kuti varwere vawane mwero wepamusoro wekuregererwa.Kuongororwa kwevarwere makumi matatu vane acute myeloid leukemia kwakaratidza kuti paclitaxel yakasanganiswa nechemotherapy yakaguma nemhinduro yakakwana. mu80% yevarwere.
10,lymphoma:Mukurapa kwenon-Hodgkin lymphoma,paclitaxel yakasanganiswa nechemotherapy mishonga yakadai secyclophosphamide inogona kuita kuti varwere vawane mhinduro yakakwana.Ongororo yevarwere makumi mana vane non-Hodgkin's lymphoma yakaratidza kuti paclitaxel yakasanganiswa chemotherapy regimen mumhinduro yakakwana mu85% yevarwere.
Mhedziso
Muchidimbu, paclitaxel yakaratidza humwe hutano mukurapa kwemhando dzakasiyana dzekenza.Zvisinei, zvakakosha kuziva kuti kushanda kwekurapa kunosiyana kune yega yega mhando yekenza uye inowanzodiwa pamwe nemamwe madhiragi. kuoma kunzwisisa uye kusiyana kwega kwegomarara, zvirongwa zvekurapa zvinofanirwa kuve zvakasarudzika kune mumwe nemumwe murwere.
Ongorora: Mabhenefiti angangodaro uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akaburitswa.
Nguva yekutumira: Nov-17-2023