Paclitaxel is one of the classic three generation chemotherapy drugs, asi kunyungudika kwayo mumvura hakuna kunaka uye inoda kunyungudutswa ne organic solvents.Albumin-bound paclitaxel inoshandisa nanotechnology kuwedzera zvinodhaka kuendeswa uye bioavailability yepaclitaxel nerubatsiro rwenatural albumin. inongodzivirira iyo hypersensitivity / toxicity reaction inokonzerwa neorganic solvents, asi zvakare haidi pretreatment yehomoni; Inogona zvakare kuita kuti albumin itakure paclitaxel kunze kwekutenderera kweropa nekukurumidza, ipfuure nepakati endothelial maseru kuburikidza nereceptor mediated endocytosis, uye kupfumisa zvakanyanya mu tumor tissues. kuburikidza nekukwirira kwepamusoro uye kuchengetedza maitiro (EPR mhedzisiro) yemamota, ayo anoenderera mberi nekuratidzira pharmacokinetic zvakanakira.
Munguva ye immunotherapy, kushanda kwemushonga mumwe chete hakuna kukwana, uye chinangwa chekuregererwa (ORR) chemushonga mumwe chete hachipfuuri 20%; Nzira yekuwedzera sei vanobatsirwa ne immunotherapy, kurapa kwakasanganiswa kunogona kuva mhinduro inoshanda, pakati payo. iyo nzira yekusanganiswa chemotherapy ndiyo nzvimbo inopisa yekuongorora ikozvino.
Kubva pamaonero aya,Albumin-bound paclitaxel ine zvayakanakira,yayo ORR yakakwira,inokwanisa kuuraya bundu maseru zvakanyanya, uye kukurudzira kuratidzwa kwebundu antigen;Hapana mahormone pretreatment anodiwa kudzivirira immunosuppression;Kuwedzera bundu matishu kunoderedza kukuvadzwa normal tissues.
Ongorora: Iko kugona kushanda uye mashandisirwo akaunzwa muchinyorwa ichi zvese zvinobva kumabhuku akadhindwa.
Yunnan Hande Biotechnology Co., Ltd yanga iri nyanzvi mukugadzirapaclitaxel APIkweanopfuura makore makumi maviri, uye ndeimwe yepasi rose yakazvimiririra inogadzira paclitaxel API, inotorwa nechirimwa anti-cancer drug, yakatenderwa neUS FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan nemamwe masangano anodzora nyika. .Hande inogona kupa kwete chete yepamusoro-soropaclitaxel mbishi zvinhu,asi zvakare tekinoroji yekusimudzira masevhisi ane chekuita ne paclitaxel formulation.Kuwana rumwe ruzivo, ndapota inzwa wakasununguka kutibata pa18187887160.
Nguva yekutumira: Zvita-29-2022