Pakukwira uku, rhythm uye kukurumidza kuyerera kwenzvimbo yekugara, vamwe vanhu vanowanzononoka kurara usiku, izvo zvinoita kuti vatadze kurara, zvichikonzera mamwe matambudziko ehope. Toita sei? Kana pane dambudziko, kuva nzira yekugadzirisa dambudziko.
Panguva iyo vanhu vazhinji vanonzwamelatonin,vanofunga kuti melatonin chigadzirwa cherunako.Kutaura zvazviri, melatonin ihomoni yemukati inokonzera kurara kwepanyama.Inokunda zvipingamupinyi zvekurara uye inovandudza kurara kwehutano nekugadzirisa kurara kwevanhu kwepanyama. batsira kurara.
Maererano nenhamba dzeWorld Health Organisation, huwandu hwehosha yekurara pasi rose i27%, inova chirwere chepfungwa chechipiri pasi rose. Anenge munhu mumwe chete pavatatu ane dambudziko rekurara uye mumwe chete pagumi anozadzisa zvinodiwa zvekuongorora. Kushaya hope.Chirevo chakaburitswa nesangano rekuongorora hope reChina chinoratidza kuti vanhu vanodarika mamiriyoni mazana matatu muChina vane dambudziko rekurara, ukuwo hurwere hwekushaya hope muvakuru hunosvika 38.2%.
Saka Melatonin inogona kubatsira kurara here? Inobatsirei?
###Ngatitarisei melatonin nebasa rayo.
Melatonin(MT) ndechimwe chehomoni inoburitswa nepineal gland.Melatonin ndeye indole heterocyclic compounds.Zita rayo remakemikari rinonzi N-acetyl-5 methoxytryptamine,inozivikanwawo sepinealoxin.After melatonin synthesis,inochengetwa mupineal gland. Kunzwa tsitsi kunokanganisa masero epineal gland kuti abudise melatonin. Kubuda kwemelatonin kune rhythm iri pachena ye circadian, iyo inorambidzwa masikati uye inoshanda usiku.
Melatonin inogona kuvharisa hypothalamic pituitary gonadal axis, kuderedza zvirimo mugonadotropin inoburitsa mahormone,gonadotropin,luteinizing hormone uye follicular estrogen, uye kuita zvakananga pane gonads kuderedza zviri mukati me androgen,estrogen uye progesterone.Ongororo yazvino inoratidza kuti melatonin ndiyo mutungamiriri-mukuru we endocrine.Inodzora zviitiko zveakasiyana endocrine glands mumuviri, nekudaro inodzora zvisina kunanga basa remuviri wedu wese.
Basa uye Regulation yeMelatonin
1) Gadzirisa circadian rhythm
Melatonin secretion ine circadian rhythm.Kuwedzera melatonin kubva kunze kwemuviri kunogona kuchengetedza chiyero che melatonin mumuviri mudiki, kugadzirisa uye kudzorera iyo circadian rhythm, kwete chete kudzamisa hope uye kunatsiridza kunaka kwekurara, asi zvakare kunatsiridza mashandiro ehutano. muviri wese,zvinonatsiridza hupenyu uye kunonoka kuchembera.Nekuda kwekuti nekukura kwezera, pineal gland inodzikira kusvika yave calcification,zvichikonzera kupera simba kana kunyangarika kweiyo rhythm yebiological clock.Kunyanya mushure memakore makumi matatu nemashanu, iyo melatonin inovanzwa nemuviri inodzikira zvakanyanya, neavhareji inodzikira ye10 ~ 15% pamakore gumi oga-oga, zvichikonzera kusagadzikana kwekurara uye nhevedzano yezvinetso zvekushanda. kuchembera.
2)Kunonoka kuchembera
Iyo pineal gland yevakwegura inoderera zvishoma nezvishoma, uye secretion ye MT inoderera zvichienderana.Kuwanda kweMel inodiwa nenhengo dzakasiyana-siyana mumuviri haina kukwana, zvichiita kuti kuchembera uye zvirwere. MT kubva kunze, tinogona kudzosa wachi yekuchembera.
3)Dzivisa maronda
Nokuti MT inogona kupinda mumasero nyore nyore, inogona kushandiswa kudzivirira DNA yenyukireya.Kana DNA yakakuvadzwa, inogona kutungamirira kukenza.Kana pane Mel yakakwana muropa, hazvisi nyore kuwana kenza.
4) Regulatory effect pane central nervous system
Nhamba huru yezvidzidzo zvekiriniki uye zvekuedza zvinoratidza kuti melatonin, senge endogenous neuroendocrine hormone, ine yakananga uye isina kunanga physiological regulation pane yepakati tsinga sisitimu, mhedzisiro yekurapa pakusagadzikana kwekurara, kushushikana uye zvirwere zvepfungwa, uye zvinodzivirira pamasero etsinga. , melatonin ine sedative effect, inogonawo kurapa kuora mwoyo uye psychosis, inogona kudzivirira tsinga, inogona kuderedza marwadzo, kugadzirisa mahomoni anobudiswa ne hypothalamus nezvimwe zvakadaro.
5) Kudzora kwe immune system
Mumakore gumi achangopfuura, kudzorwa kwe melatonin pa immune system yakwezva kutarisisa kwakapararira. Ongororo yakaitwa kumba nekune dzimwe nyika yakaratidza kuti melatonin haingokanganisa kukura nekukura kwenhengo dzemuviri dzinodzivirira zvirwere, asiwo inodzora humoral immune immune, cellular immune uye cytokines. Semuyenzaniso, melatonin anogona kudzora masero uye humoral kusadzivirirwa, uyewo basa akasiyana cytokines.
6) Regulatory effect pane yemwoyo system
Basa revascular system rine pachena circadian rhythm uye seasonal rhythm, kusanganisira BP, chiyero chemoyo, kubuda kwemwoyo, renin angiotensin aldosterone, nezvimwewo. Iyo serum melatonin secretion level inogona kuratidza nguva inoenderana yezuva uye mwaka unoenderana wegore. .Uyezve, mhedzisiro yekuedza yakakodzera yakasimbisa kuti kuwedzera kweMT secretion husiku kwakabatana zvisina kunaka nekuderera kwemoyo wemoyo; Pineal melatonin inogona kudzivirira arrhythmia inokonzerwa neischemia-reperfusion kukuvara, inokanganisa kudzora kweropa, kutonga kuyerera kwehuropi, uye. gadzirisa reactivity yeperipheral arteries kune norepinephrine.
7) Pamusoro pezvo, melatonin inodzorawo hurongwa hwekufema kwevanhu, digestive system uye weti system.
Mazano eMelatonin
melatoninhausi mushonga.Unogona chete kuita basa rekubatsira mukusarara uye hauna mushonga wekurapa.Kune matambudziko akadai sekurara kusina kunaka uye kumuka pakati, hazvizove nemhedzisiro yekuvandudza.Muzviitiko izvi, unofanirwa kutsvaga kurapwa. nekufamba kwenguva uye kuwana kurapwa kwezvinodhaka.
Unoda kuziva zvakawanda nezve melatonin?Hande yakazvipira kupa vatengi zvinhu zviri nani uye zvine hutano zvekubvisa zvigadzirwa.Tinopa zvemhando yepamusoro uye zvemhando yepamusoro melatonin zvigadzirwa kuti zvinyatso kukubatsira kuvandudza kurara kwako uye kurarama zvakanaka mazuva ese!
Nguva yekutumira: May-11-2022