Paclitaxel chigadzirwa chechisikigo chakabviswa muTaxus, chinoshanda pa tubulin kuvharidzira mitosis ye tumor cell.Kusvika pari zvino, paclitaxel ndiyo yakanyanya kunaka inorwisa cancer yemushonga wawanikwa.Iyo yakakura-spectrum chemotherapy drug, uye ine kuita kwakanaka kwekiriniki mukurapa kenza yemazamu, kenza yeovarian, isiri-diki cell kenza yemapapu, gastroesophageal cancer uye mamwe mamota.
Nekuti yechinyakare paclitaxel ine lipophilic yakanyanya, uye iyo inoshanda musanganiswa inonetsa kunyungudika mumvura, anhydrous ethanol, polyoxyethylene castor mafuta, nezvimwewo zvinoshandiswa mukugadzira nzira yekuibatsira kunyungudika. uye mumatambudziko akaoma, anaphylactic shock inogona kuitika, ichiisa upenyu pangozi. Chiitiko chekusawirirana kweropa chinosvika 20% -40% .Kuti kudzivirirwa kunoshanda, kurapwa necorticosteroids uye antihistamines kunofanira kuitwa kusati kwaitwa.Paclitaxel inoda diluted yakawanda pamberi pejekiseni remutsinga, uye nguva yekupinza inoda kuchengetwa ingangoita maawa matatu.
Kuti tikunde chikanganiso ichi, albumin-bound paclitaxel yakavapo.Albumin-bound paclitaxel inobatanidza hydrophobic paclitaxel nealbumin kuti iite nanoparticles ine particle size inokwana 130 nm kuburikidza nekushandisa nanotechnology yakasiyana.Inoshandisa nzira yakasiyana yekutakura albumin kuita kuti paclitaxel iwedzere kugovaniswa mumabundu matishu uye inosvika pakakwirira mumasero ebundu; Inodzivirira kushandiswa kweanhydrous ethanol, polyoxyethylene castor mafuta uye zvimwe zvinonyungudutswa, inoderedza zvakanyanya kuitika kweallergic reaction, uye haidi anti allergic pretreatment isati yashandiswa. ,uye haadi kushandisa yakakosha infusion device.The infusion inogona kupedzwa muhafu yeawa.Inonyatsoita yakakwira kurapa mhedzisiro uye yakaderera chepfu.
Ongorora: Iko kugona kushanda uye mashandisirwo akaunzwa muchinyorwa ichi zvese zvinobva kumabhuku akadhindwa.
Yunnan Hande Biotechnology Co., Ltd yanga iri nyanzvi mukugadzirapaclitaxel APIkweanopfuura makore makumi maviri, uye ndeimwe yepasi rose yakazvimiririra inogadzira paclitaxel API, inotorwa nechirimwa anti-cancer drug, yakatenderwa neUS FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan nemamwe masangano anodzora nyika. .Hande inogona kupa kwete chete yepamusoro-soropaclitaxel mbishi zvinhu,asi zvakare tekinoroji yekusimudzira masevhisi ane chekuita ne paclitaxel formulation.Kuwana rumwe ruzivo, ndapota inzwa wakasununguka kutibata pa18187887160.
Nguva yekutumira: Zvita-21-2022