Paclitaxel (Paclitaxel) mushonga wechisikigo anticancer wakatorwa kubva kune yew chirimwa, ine yakasarudzika makemikari chimiro uye pharmacological mhedzisiro.Kubva pakawanikwa paclitaxel muna 1971, kushanda kwayo kwekiriniki kwakawana mhedzisiro inoshamisa.Mupepa iri, chimiro chemakemikari uye pharmacological chiito chepaclitaxelichakurukurwa.
Kemikari chimiro che paclitaxel
Iyo kemikari chimiro che paclitaxel chakaomarara, chinosanganisira akati wandei mhete zvimiro, kusanganisira musimboti diterpenoid chimiro, chinova chikamu chakakosha cheiyo anti-cancer mhedzisiro ye paclitaxel.Paclitaxel mamorekuru anewo akati wandei ehydroxyl uye ketone mapoka, uye nzvimbo uye nhamba yemapoka aya inosarudza yakasarudzika pharmacological chiitiko.
Iyo pharmacological mhedzisiro ye paclitaxel
1. Microtubule stabilization: Paclitaxel inogona kukurudzira polymerization ye microtubules uye kudzikamisa iyo polymerized microtubules, iyo inonyanya kushandiswa kweiyo anticancer effect.Microtubules inoita basa rakakosha mukupatsanurwa kwesero, uye paclitaxel inhibits bundu kukura nekudzikamisa microtubules uye kudzivirira kupatsanurwa kwesero.
2, induce cell cycle kusungwa: paclitaxel inogonawo kukonzera kusungwa kwesero kutenderera, kuitira kuti maseru asarambe achipatsanura uye kuwanda.Iyi ndiyo imwe nzira yakakosha yeayo anticancer effect.
3, induce apoptosis: paclitaxel inogona kukurudzira kutaura kwevanoverengeka pro-apoptosis varevereri, kumhanyisa apoptosis maitiro ekenza maseru.
4, mutemo wevanopesana neapoptotic mediators: paclitaxel inogonawo kudzora basa reanopoptotic mediators kuenzanisa maitiro eapoptosis uye kuwanda.
Mhedziso
Paclitaxel imhando yechisikigo anticancer drug ine yakasarudzika makemikari chimiro uye pharmacological chiito.Inogona kunyatso kumisa bundu kukura nekusimudzira microtubule polymerization, kudzikamisa mapolymerized microtubules, inducing cell cycle kusungwa uye inducing cell apoptosis.Nekudaro, iyo muchetura uye mhedzisiro ye paclitaxel zvakare kunetsekana mumakiriniki ekushandisa.Kuwedzera kutsvagisa uye kunzwisisa kweiyo pharmacological mhedzisiro ye paclitaxel ichabatsira kukwidziridza kushandiswa kwayo kwekiriniki, kunatsiridza kurapa kwakanaka, uye kuderedza mhedzisiro.
Ramangwana Outlook
Kunyangwe kiriniki yekushandiswa kwepaclitaxel yakawana mhedzisiro inoshamisa, dambudziko rezviwanikwa zvayo zvishoma uye kusimba kwekupa kuchiripo.Naizvozvo, masayendisiti ari mumunda wesynthetic biology uye chemistry yekurapa ari kushanda kutsvaga dzimwe nzira dzepaclitaxel kugadzirisa matambudziko ayo ekupa uye kuderedza mitengo yekugadzira.Uye zvakare, tsvagurudza mune zvemishonga mhedzisiro yepaclitaxelzvichabatsirawo kutsvaga nzira dzekurapa dzinoshanda dzekurwisa mhando dzakasiyana dzegomarara.
Muzvidzidzo zvepreclinical uye miedzo yekiriniki, musanganiswa wepaclitaxel nemimwe mishonga yeanticancer yakaratidza tarisiro inovimbisa.Nekubatanidza paclitaxel nemamwe madhiragi, kushanda kwekurapa kunogona kuvandudzwa uye kubuda kwekupokana kunoderedzwa.Mune ramangwana, nekuzivikanwa kwemushonga chaiwo uye mazano ekurapa ega, kutsvagisa uye kunzwisiswa kweiyo pharmacological mhedzisiro ye paclitaxel ichave yakadzama, uye mamwe echokwadi uye anoshanda zvirongwa zvekurapa zvichapihwa varwere vegomarara.
Kazhinji, paclitaxel ndeye yakasikwa anticancer drug ine yakasarudzika makemikari chimiro uye pharmacological mhedzisiro.Nekuenderera mberi kwekuenderera mberi kwesainzi uye tekinoroji uye nekutsvaga kwakadzama, isu tinotarisirapaclitaxelkuita basa guru mukurapa kwegomarara rakasiyana-siyana mune ramangwana, kuunza kurapwa kuri nani uye hupenyu hwevarwere.
Ongorora: Mabhenefiti angangoitwa uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akadhindwa.
Nguva yekutumira: Nov-15-2023