Semi-synthetic paclitaxel inogadzirwa sei?

Paclitaxel, a natural anti-cancer drug, rinonyanya kutorwa kubva kuTaxus chinensis.Iyo yakashandiswa zvakanyanya mukurapa gomarara rezamu, gomarara reovarian, uye imwe kenza yeMusoro nemutsipa nekenza yemapapu.Paclitaxel yakakamurwa kuita zvakasikwa.paclitaxeluyeSemi-synthetic paclitaxel.Pazasi, ngatitarisei kuti Semi-synthetic paclitaxel inogadzirwa sei.

Sezvo natural paclitaxel yakabviswa muTaxus chinensis ine mashoma masosi, uye kutenderera kwechisikigo Taxus chinensis kureba, chete ingangoita 13.6kg bark inogona kubvisa 1g ye paclitaxel, uye zvinotora 3 kusvika gumi nemiti yemitero ine nhoroondo yemakore anopfuura zana. kurapa murwere wegomarara reovarian, kushomeka kwenguva refu kwekupihwa uye mutengo wakakwira zvinoita kuti tekinoroji yekugadzira synthesis ye paclitaxel ikure nekukurumidza.

Sechinhu chakatorwa kubva mumiti yechisikigo, paclitaxel ine chimiro chakaoma.Zvisinei, kugadzirisa kushomeka kwezvinhu zvinogadzirwa, vemakemikari kubva pasirese vari kudzidza nezve synthesis ye paclitaxel.Kusvikira mumwe chiremba wemakemikari wekuFrance apatsanura chinhu chinonzi10-DABkubva pamashizha eBritish Taxus chinensis,chimiro chayo chaive chakada kufanana nechepaclitaxel,uye chirimo chaive chakakwirira.Mashizha acho aidzoreredza kupfuura makwati nemapazi,uye aive nekukuvara kushoma kuTaxus chinensis.

Kuburikidza nekuedza kusingagumi kwemasayendisiti, nzira yeSemi-synthetic paclitaxelyakazogadzirwa, uye hazvichadikani kutema Taxus chinensis kuti iburitswe. Zvino, nekudzidza chimiro che paclitaxel, mamwe machemical drugs akaita sedocetaxel nealbumin paclitaxel akagadzirwa, achiunza mamwe mishonga yekurapa kuvarwere vegomarara.

Tsanangudzo:Kugona kuita uye mashandisirwo ataurwa muchinyorwa chino zvese zvinobva mumabhuku anowanikwa pachena.

Kuwedzera kuverenga:Hande Bio-tech inonyanya kuita kudhirowa nekusimudzira taxanes.Zvigadzirwa zvayo zvepakati ndezvepaclitaxel,10-DAB Semi-synthetic paclitaxel,10-DABIII,docetaxel,cabataxel,etc.Kana uchida kuziva nezve paclitaxel. based APIs, ndapota inzwa wakasununguka kutibata nesu.