Natural Paclitaxel VS Semi-synthetic Paclitaxel (I)

Mushonga Wemudziyo

Paclitaxel, semushonga unorwisa cancer, inoshandiswa zvakanyanya mumajekiseni akasiyana siyana nemidziyo.

Inonyanya kugadzirwa nekutorwa kwechisikigo uye synthesis.

Sezvo chirimwa chinobva paclitaxel, Taxus Chinensis, chiri kushomeka uye chine nguva yakareba yekukura, nhevedzano yenzira dzekubatanidza dzakatorwa zvishoma nezvishoma kubva paclitaxel kuburikidza nekutsvaga uye kuyedza kutenderera pasirese, kusanganisira yakazara synthesis, semi-synthesis, uye. endophytic synthesis.

Nekuda kwekureba kwemakemikari synthesis nzira, akawanda ekubatanidza nhanho, uye yakaoma kudzora maitiro ekuita, iyo paclitaxel yakanyatsogadzirwa inoda kushandisa anodhura emakemikari reagents, uye goho zvakare rakaderera, risingakodzere kugadzirwa kwakawanda uye kugadzirwa kwemaindasitiri mu. general.

Naizvozvo, huwandu hwakakura hwepaclitaxel mumusika unowanzo gadzirwa nekutorwa kwechisikigo kweyakarimwa taxus uye semi-synthetic nzira.

Natural Paclitaxel vs Semi-synthetic Paclitaxel

Chikamu 1:Kugadzira Maitiro

Natural paclitaxel:

-Raw zvinhu: Yakasimwa Yew

-Kubvisa maitiro:raw material+column chromatography+recrystallization = yapera chigadzirwa

-Kubvisa maitiro: kuita kwemuviri, hapana makemikari synthesis maitiro

Semi-synthetic Paclitaxel:

-Raw zvinhu: Yakasimwa Yew

-Kubvisa maitiro:raw material+kemikari reagent reaction+yakanyanya crystallization+yakasiyana siyana kemikemikari maitiro+recrystallization = yapera chigadzirwa

-Kubvisa maitiro: kemikari yekuita

Panyaya yetekinoroji, yakasikwa paclitaxel ine nhanho dzakareruka dzekubvisa zvichienzaniswa nesemi-synthetic paclitaxel uye mamwe mabhenefiti pamusoro pe semi-synthetic paclitaxel maererano nekugadzikana uye kuchengetedzeka, nepo semi-synthetic paclitaxel inoderedza mutengo wekugadzirwa kwechigadzirwa maererano nemutengo uye zvigadzirwa. ,uye zvakare inovandudza mamwe matambudziko anokonzerwa nekushaikwa kwezvinhu zvinogadzirwa pamusika.

Zvichienzaniswa nenzira mbiri dzekugadzira paclitaxel,natural paclitaxel ine kugadzikana kuri nani uye kuchengetedzeka mumidziyo yekurapa, chinova chimwe chikonzero nei mazhinji makambani emidziyo yekurapa ari pamusika anoshandisa yakasikwa paclitaxel seyakabikwa.

Yunnan Hande Biotechnology Co., Ltd. yave nemakore makumi matatu ichiita basa rekuchera nekugadzira mitero, uye zvigadzirwa zvayo zvepakati ndezve paclitaxel, 10-DAB semi-synthetic paclitaxel, 10-deacetylbaccatin III, docetaxel, cabazitaxel, nezvimwewo. rumwe ruzivo nezve paclitaxel APIs, ndapota taura nesu !!!(Whatsapp/Wechat:+86 18187887160)