Paclitaxel mushonga unopesana negomarara unoshandiswa kurapa marudzi mazhinji egomarara, wakatanga kutorwa kubva pamakwati emuti wePacific yew (Taxus pacifica) uye wakazogadzirwa nenzira dzekugadzira.Paclitaxelndeyeboka remishonga inonzi microtubule stabilizers.
Iyo anti-cancer nzira yepaclitaxelinosanganisira zvinhu zvakawanda, kunyanya zvinosanganisira zvinotevera:
1.Kuwedzera kugadzikana kwe microtubule: Paclitaxel inodzivirira kugadzikana kwemaitiro emagetsi e microtubules nekusunga kune tubulin, iyo inhengo ye cytoskeleton.Izvi zvinokonzera kuti microtubules irege kuputsa uye kurongazve, kudzivirira kupatsanurwa kwemasero uye kukura.Kuparadzaniswa kwemasero ekenza ndiko chinhu chakakosha chegomarara, saka kudzivirira kupatsanurwa kwesero nekudzikamisa microtubules ndiyo yakakosha anticancer maitiro epaclitaxel.
2.Kusungwa kweCell cycle: Paclitaxel inogonawo kukonzera kusungwa kwesero, izvo zvinokonzera kuti masero emukenza amire mune imwe nzvimbo yemasero ekutenderera, kazhinji mitosis.Izvi zvinobatsirawo kuderedza kukura uye kupatsanurwa kwemasero emukenza.
3.Inosimudzira apoptosis:Paclitaxel inogona kudzivisa kukura kwekenza kuburikidza nekuita kuti masero ekenza akakuvadzwa kana asina kujairika apinde apoptosis(programmed cell death) .Iyi inzira yechisikigo inofa inobatsira kubvisa masero asina kujairika.
4.Anti-angiogenesis:Paclitaxelinogona zvakare kutadzisa kuumbwa kwetsinga itsva dzeropa dzakatenderedza masero egomarara, zvinove zvakakosha kuti bundu rikure uye ripararire. Nekudzivirira kuumbwa kwetsinga itsva dzeropa, zvinogona kuderedza kubuda kweropa kune bundu, nokudaro zvichidzikamisa bundu kukura.
Pakazere, paclitaxel mushonga unokanganisa kukura uye kupatsanurwa kwemaseru egomarara, uchishanda pamasero egomarara kuburikidza nenzira dzakasiyana siyana, uye nekudaro unoshandiswa zvakanyanya mumhando dzakawanda dzekurapa cancer.
Ongorora: Mabhenefiti angangodaro uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akaburitswa.
Yunnan Hande Biotechnology Co., Ltd. yakatarisana nekugadzirwa kwepaclitaxelkwemakore makumi maviri nematanhatu, uye inogadzira yakazvimiririra yemiti-yakabviswa anti-cancer drug paclitaxel API yakabvumidzwa neUnited States FDA,European EDQM,Australia TGA,China CFDA,India,Japan nemamwe masangano anodzora nyika.Yunnan Hande paclitaxel,spot supply ,fekitari yakananga kutengesa, tinogamuchirwa kubvunza,18187887160(WhatsApp nhamba imwecheteyo)
Nguva yekutumira: Oct-11-2023