Maitiro ekugadzira ePaclitaxel, mushonga unoshandiswa zvakanyanya mukurapa cancer, inzira yakaoma uye yakaomesesa inovhara matanho akati wandei, kubva pakutorwa kubva kune zvakasikwa masosi kusvika kune yekupedzisira kugadzirwa kwemishonga.Iri bepa richasuma maitiro ekugadzirwa kwepaclitaxel, kubva pakutorwa kusvika pakugadzirira.
Danho 1: Bvisa
Paclitaxelyakatanga kutorwa kubva pamakwati emuti wePacific yew, Taxus pacifica.Iyo nzira inotanga nekuunganidza bark uye kazhinji inoda kuchenjerera kubata kudzivirira kukuvadza kumuti.Makwati akaunganidzwa anobva atyorwa oiswa mumushonga wakakodzera, wakaita seether kana xylene.Paclitaxel inonyungudutswa kubva pagwati kuita munyungudusi mune ino nhanho kugadzira inobvisa.
Danho rechipiri: Kuparadzana
Zvinyorwa zvinowanzove nemhando dzakasiyana dzemakomisheni, saka paclitaxel inoda kupatsanurwa kubva kune mamwe makomisheni.Iyi nhanho inowanzo shandisa chromatographic chromatography kana imwe nzira yekuparadzanisa kuparadzanisa paclitaxel kubva kune zvimwe zvinhu zvichienderana nehunhu hwekomboni.
Danho rechitatu: Kucheneswa
Iyo paclitaxel yakapatsanurwa inoda kucheneswa zvakare kubvisa chero tsvina yasara uye kuwana chigadzirwa chakanyanya kuchena.Izvi zvinowanzobatanidza matanho akadai sekristaro, kusefa, uye recrystallization kuti ive nechokwadi chekuti paclitaxel yekupedzisira ndeyekuchena kwakanyanya.
Nhanho 4: Synthesis (kusarudza)
Kunyangwe iyo yekutanga paclitaxel yakatorwa kubva kune yakasarudzika masosi, akati wandei makambani emishonga akagadzira nzira dzekuisanganisa.Idzi nzira dzinoshandisa nzira dzemakemikari dzekugadzira kuwedzera goho uye kutonga uye kuderedza kuvimba nezviwanikwa.
Danho rechishanu: Gadzirira mushonga
Nhanho yekupedzisira mukugadzirwa kwekugadzira ndiko kugadzirira kwepaclitaxel yakacheneswa kuita gadziriro yekushandiswa kwekurapa.Izvi zvinogona kusanganisira kunyungudutsa paclitaxel mune inonyungudutsa yakakodzera, yakadai sedoro kana ether, kuti igadzirire kuita gadziriro yemishonga.Iyo yakajairika fomu inogadzirirwa semushonga wejekiseni kuti uve nechokwadi chedosing chaiyo.
Kutorwa pamwe chete, nzira yekugadzira yepaclitaxelinzira yakaoma uye yakawanda-nhanho yakagadzirirwa kuve nechokwadi chekuchena kwepamusoro uye kudzoreka kwemushonga wekupedzisira.Kubudirira kwechirongwa ichi kwakakosha pakuendeswa kwekurapa gomarara kunoshanda uye nekudaro iri kugara ichivandudzwa nekugadziridzwa kuti ienderane nezvido zvekurapa.
Ongorora: Mabhenefiti angangoitwa uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akadhindwa.
Yunnan Hande Biotechnology Co., Ltd yakatarisana nekugadzirwa kwepaclitaxel kwemakore makumi maviri nematanhatu, uye inogadzira yakazvimiririra yemiti-yakabviswa inorwisa cancer drug paclitaxel API yakabvumidzwa neUnited States FDA, European EDQM, Australia TGA, China CFDA. , India, Japan uye mamwe masangano anodzora nyika.Yunnan Hande paclitaxel, nzvimbo yekutengesa, fekitori yakananga kutengesa, kugamuchirwa kubvunza, 18187887160 (WhatsApp nhamba imwecheteyo)
Nguva yekutumira: Oct-13-2023