Paclitaxel chigadzirwa chepanyama chakatanga kutorwa kubva pamakwati emuti wePacific yew (Taxus pacifica). Iyo biosynthesis ye paclitaxel inosanganisira yakaoma biosynthetic nzira, kusanganisira akawanda ma enzymes uye epakati. inonetsa mukugadzirwa kwemaindasitiri.Heino tarisiro yakajairika ye paclitaxel biosynthesis:
1.Kutanga zvinhu: Iyo biosynthesis ye paclitaxel inotanga neyakagadzika kutanga zvinhu, kazhinji kubva pamashizha kana makwati emuti weyew.Izvi zvokutanga zvinhu zvine macomputer evabereki anogona kushandiswa kugadzira paclitaxel's precursors.
2.Multi-enzyme catalysis:Biosynthesis yepaclitaxelzvinoda maenzayimu akawanda kuti agadzirise maitiro.Maenzayimu aya anoshandura chinhu chinotanga kuita chepakati izvo zvishoma nezvishoma zvinogadzira paclitaxel's precursor molecules.
3.Synthesis of intermediates: Intermediates inhanho inokosha mukugadzirwa kwepaclitaxel.Iyo inosanganisira polycyclic compounds uye mashizha emaketani emaketani anogadzirwa zvishoma nezvishoma kuburikidza nehuwandu hwekuita kwe enzyme-catalyzed.
4.Final synthesis ye paclitaxel:Iyo precursor molecules for the synthesis ye paclitaxel inogadzirwa zvishoma nezvishoma kuita paclitaxel molecules in multiple reaction steps.Izvi zviito zvinosanganisira polycyclic synthesis,acylation,deketone, uye mamwe matanho anokosha.
5.Kubvisa uye kucheneswa: Mushure mekugadzirwa kwepaclitaxel, danho rekubvisa uye rekucheneswa rinodiwa kuparadzanisa yakachena paclitaxel kubva musanganiswa wekuita.
Kunyangwe zvakasikwa biosynthetic nzira dzepaclitaxeldzakadzidzwa, kugadzirwa chaiko kwepaclitaxel kunoramba kwakaoma nekuti kunoda kuumbwa kwakaoma nematanho akawanda uye yakawanda yezvigadzirwa.Nekuda kwezvipingamupinyi izvi, masayendisiti akaongororawo nzira dzekugadzira kugadzira paclitaxel kuti iwedzere goho uye kuwanikwa kwayo.Synthetic synthesis ye paclitaxel inowanzo sanganisira yakareruka nzira yekubatanidza kuderedza kuoma.
Ongorora: Mabhenefiti angangodaro uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akaburitswa.
Yunnan Hande Biotechnology Co., Ltd. yanga yakatarisana nekugadzirwa kwepaclitaxel kwemakore makumi maviri nematanhatu, uye inogadzira yakazvimirira yemiti-yakabviswa mushonga wekurwisa cancer paclitaxel API yakabvumidzwa neUnited States FDA,European EDQM,Australia TGA,China CFDA. ,India,Japan nemamwe masangano anodzora nyika.Yunnan Hande paclitaxel,spot supply,factory direct sales,tinogamuchira kubvunza,18187887160(WhatsApp nhamba imwe cheteyo)
Nguva yekutumira: Oct-12-2023