Paclitaxel inoshandiswa zvakanyanya kushandiswa kwechirwere chegomarara, pakutanga yakabva kuPacific yew tree (Taxus brevifolia) .Zvisinei, nzira yekutora kubva pamuti uyu yakakonzera kusagadzirisa kwezvakatipoteredza, zvichiita kuti masayendisiti atsvake mamwe matsime akasimba kuti asangane nezvido zvekurapa. Ichi chinyorwa chinoongorora mabviro epaclitaxel, dzimwe nzira, uye budiriro yeramangwana.
Paclitaxelmushonga unoshanda unorwisa cancer unoshandiswa kurapa marudzi akasiyana-siyana egomarara, kusanganisira kenza yeovarian, kenza yemazamu, uye isiri diki kenza yemapapu.Kunyange zvakadaro, nzira yakapfuura yekubvisa yainyanya kuvimba nekukohwa bark nemashizha emuti wePacific yew, zvichitungamira kuderera kwakanyanya kwehuwandu hwemiti iyi. Izvi zvakasimudza kushushikana kwezvakatipoteredza, sezvo miti iyi inokura zvishoma nezvishoma uye isina kunyatsokodzera kukohwa kukuru.
Kuti vagadzirise nyaya iyi, vesainzi vanga vachitsvaga mamwe mabviro uye nzira dzekuti vawane paclitaxel.Hedzino dzimwe nzira dziri kudzidzwa parizvino:
1.Taxus yunnanensis:Muti uyu wew, wekuChina, unewo paclitaxel.Vatsvakurudzi vanga vachitsvaga mukana wekutora paclitaxel kubva kuTaxus yunnanensis, iyo inogona kubatsira kuderedza kutsamira paPacific yew tree.
2.Chemical Synthesis:Masayendisiti anga achiongorora nzira dzekugadzira makemikari paclitaxel.Kunyange iyi iri nzira inoshanda, inowanzobatanidza matanho akaomarara ekugadzira organic uye inodhura.
3.Fermentation:Kushandisa microbial fermentation kuti ibudise paclitaxel imwe nzvimbo yekutsvakurudza.Iyi nzira inobata chivimbiso chekuderedza kuvimba nekudyara kwemiti.
4.Zvimwe Zvirimwa:Kuwedzera kune Pacific yew uye Taxus yunnanensis, zvimwe zvinomera zviri kuongororwa kuti zvione kana paclitaxel inogona kutorwa kubva mazviri.
Nepo kutsvaga kwemamwe masosi akasimba epaclitaxel kuri kuenderera mberi, kunokosha zvakanyanya.Kunogona kuderedza kudzvanywa kwehuwandu hwemiti yePacific yew, kuchengetedza zvakatipoteredza, uye kuve nechokwadi kuti varwere vanoramba vachibatsirwa nemushonga uyu unokosha wekurwisa cancer.Zvisinei, chero chitsva nzira yekugadzira inofanirwa kuomesesa kusimbiswa kwesainzi uye ongororo yekudzora kuti ive nechokwadi chemhando uye kuchengetedzeka kwemushonga.
Mukupedzisa, kutsvaga kwemamwe masosi akasimba epaclitaxelinzvimbo inokosha yekutsvakurudza iyo ine mukana wekufambisa kubudirira kwakasimba mukurapa kenza apo ichichengetedza mamiriro echisikigo.Kutsvakurudza kwesayenzi yeramangwana uye hutsva hwetekinoroji hucharamba huchitipa dzimwe nzira dzakasiyana dzekuzadzisa zvido zvekurapa.
Nguva yekutumira: Oct-23-2023