Paclitaxel ndeye yakasikwa yechipiri metabolite yakaparadzaniswa uye yakacheneswa kubva pamakwati efiri tsvuku.Izvo zvave zvichiratidzwa nekiriniki kuti zvine yakanaka anti-tumor mhedzisiro, kunyanya pane ovarian, uterine uye kenza yemazamu, iyo ine chiitiko chakanyanya chegomarara.Parizvino,natural paclitaxeluye semi-synthetic paclitaxel inowanikwa mumusika.Chinyorwa chinotevera chinokutora iwe nenzira ye paclitaxel synthesis.
Paclitaxelinotorwa kubva pamakwati nemashizha emuti uyu, uye nzira yekuchera yakaoma zvikuru, isingasviki mumvura nedoro, uye zvinyorwa zvakaderera zvikuru, 100g chete, kureva matani maviri epaclitaxel, anogona kutorwa kubva pamatani makumi matatu emakwenzi akaomeswa. .Kunyangwe kuumbwa kwayo kwemakemikari kwakapedzwa murabhoritari, kunosanganisira maitiro mazhinji, maitiro akaomarara, mutengo wakakwira uye goho rakaderera.Naizvozvo, haisati yave kukwanisa kuigadzira mumaindasitiri nemakemikari akazara synthesis, izvo zvinoita kuti idhure.
Kubva zvakasikwapaclitaxelinotorwa kubva kuPacific yew, iyo isingawanzo kuwanikwa, uye kukura kweyew yechisikigo kwakareba, inenge 13.6 kg yemakwati kuti ibvise 1 gramu ye paclitaxel, uye 3-12 yew miti inopfuura makore zana inodiwa kurapa imwe ovarian. murwere wegomarara, kupihwa kwenguva refu uye mutengo wakakwira zvakatungamira kukurumidza kukura kweiyo synthetic tekinoroji ye paclitaxel.
Parizvino, iyo huru nzira ye paclitaxel synthesis ndiyo bioengineering nzira, inozivikanwawo se paclitaxel semisynthesis.Iyo bioengineering nzira inoshandiswa kugadzira paclitaxel pamwero wakakura nekuberekesa uye kuongorora madhiri anogona kuburitsa huwandu hukuru hwepaclitaxel, uyezve nekuenderera mberi nekuvagadzira, vachichinja uye nekugadzirisa genetic chimiro chavo, paclitaxel inogona kugadzirwa mune yetsika svikiro "pasina. kumisikidza”, uye haichaganhurirwi nekushaikwa kwezvinhu zvinogadzirwa.Mhedzisiro yetsvagiridzo yazvino inoratidza kuti kuita kwe synthesis kwakavandudzwa zvakanyanya nekuburitsa goho kwe448.52 micrograms ye paclitaxel parita yetsika yepakati.
Kemikari synthesis, kunyangwe yakapedzwa, haina basa mumaindasitiri nekuda kwemamiriro akaomarara anodiwa, goho rakaderera, uye kudhura kwakanyanya.Iyo semi-synthetic nzira ye paclitaxel yatokura uye inoonekwa senzira inoshanda yekuwedzera sosi ye paclitaxel kunze kwekurima kwekugadzira.Iyo semi-synthetic nzira inogona kushandisa zvakanyanya zviwanikwa zvechirimwa.
Ongorora: Iko kugona kushanda uye mashandisirwo akafukidzwa mupepa rino anoratidzwa kubva kumabhuku akadhindwa.
Kuwedzera kuverenga:Yunnan Hande Biotechnology Co., Ltd yanga yakatarisana nekugadzirwa kwepaclitaxel kwemakore makumi maviri nemasere.Ndiyo yekutanga yakazvimirira kugadzira pasi rose-yakagadzirwa anticancer drug paclitaxel iyo yakatenderwa neUS FDA, European EDQM, Australian TGA, China CFDA, India, Japan nemamwe masangano anodzora nyika.enterprise.Kana uchida kutengaPurogiramu inonzi Paclitaxel, ndapota taura nesu paIndaneti.
Nguva yekutumira: Oct-08-2022