Kuvandudzwa kwepaclitaxel inyaya izere nekumonyoroka uye kutendeuka uye matambudziko, ayo akatanga nekuwanikwa kwechinhu chinoshanda mu taxus taxus, yakapfuura makumi emakore ekutsvagisa nekusimudzira, uye pakupedzisira yakave inoshandiswa zvakanyanya anticancer mushonga mukiriniki.
Mumakore ekuma1960, National Cancer Institute neDhipatimendi Rezvekurima reUS vakabatirana pachirongwa chekuongorora sampuli yechirimwa kuti vawane mishonga mitsva yegomarara.Muna 1962, Barclay, nyanzvi yemiti, akaunganidza makwati nemashizha kubva mudunhu reWashington ndokuvatumira kuNCI kunoongororwa basa rekurwisa gomarara.Mushure mekuedza kwakatevedzana, timu inotungamirwa naDr. Wall naDr. Wani yakazoisa yoga paclitaxel muna 1966.
Kuwanikwa kwepaclitaxel kwakakwezva kutarisisa kwakawanda uye kwakatanga hukuru hwekutsvagisa nekusimudzira maitiro.Mumakore akatevera, masayendisiti akaita ongororo dzakadzama dzechimiro chemakemikari epaclitaxel uye akatsunga maitiro ayo akaomarara.Muna 1971, chikwata chaDr. Wani chakasimbisa chimiro chekristaro uye NMRpaclitaxel, kuisa hwaro hwekushandiswa kwayo kwekiriniki.
Paclitaxel yaita zvakanaka mumakiriniki ekuyedzwa uye yave mutsara wekutanga kurapwa kwezamu negomarara reovarian uye mamwe musoro, mutsipa nemapapu.Nekudaro, zviwanikwa zvepaclitaxel zvakashomeka, izvo zvinoganhurira kushanda kwayo kwekiriniki kwakakura.Kuti vagadzirise dambudziko iri, masayendisiti akaita nhamba huru yezvidzidzo kuongorora synthesis ye paclitaxel.Mushure memakore mazhinji ekuedza, vanhu vakagadzira nzira dzakasiyana dzekugadzira paclitaxel, kusanganisira yakazara synthesis uye semi-synthesis.
Mune ramangwana, tsvakurudzo yepaclitaxelicharamba ichidzika.Nekuenderera mberi nekuenderera mberi kwesainzi uye tekinoroji, vanhu vanotarisirwa kuwana zvimwe bioactive zvinhu zvine chekuita ne paclitaxel uye nekunzwisisa maitiro ayo ekuita.Panguva imwecheteyo, nekuenderera mberi kwekuvandudza tekinoroji yekugadzira, iyo paclitaxel synthesis ichave yakanyatso shanda uye ine hushamwari kwezvakatipoteredza, kuitira kuti ipe vimbiso iri nani kune yayo yakakura kiriniki application.Pamusoro pezvo, masayendisiti anozoongororawo kushandiswa kwepaclitaxel mukubatana nemamwe madhiragi ekurwisa cancer kuti ape mamwe maitiro ekurapa anoshanda.
Muchidimbu,paclitaxelmushonga wechisikigo wekurwisa cancer une kukosha kwemushonga wakakosha, uye maitiro ayo ekutsvagisa nekusimudzira azere nematambudziko uye kubudirira.Mune ramangwana, nekuenderera mberi kwesainzi uye tekinoroji uye kutsvagisa kwakadzama, paclitaxel inotarisirwa kuita basa rakakosha mukurapa mamwe marudzi egomarara.
Ongorora: Mabhenefiti angangoitwa uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akadhindwa.
Nguva yekutumira: Nov-13-2023