Mishonga yePaclitaxel yakaonekwa seyekutanga kurapa cancer yemazamu, uye inoshandiswa zvakanyanya kukiriniki yegomarara reovarian, kenza yemapapu, musoro nemutsipa bundu, kenza yesophageal, gomarara remudumbu uye nyoro nyoro sarcoma.Mumakore achangopfuura, kuburikidza nekuenderera mberi kwekuongorora kwepaclitaxel zvinodhaka uye kuenderera mberi kwekuvandudzwa kwemaitiro ekugadzira, mishonga iyi ikozvino inonyanya kusanganisira paclitaxel jekiseni, docetaxel (docetaxel), liposomal paclitaxel uye albumin-bound paclitaxel.Saka ndeupi musiyano uripo pakati peiyi paclitaxel zvinodhaka, ngatidzidzei zvakawanda nezvavo pazasi.
I. Misiyano mumabasa anokosha
1. Paclitaxel jekiseni: Inoratidzwa kune yekutanga-mutsara uye yekutevera kurapwa kweinoenderera mberi ovarian cancer, adjuvant kurapwa kwelymph node-positive kenza yemazamu mushure meyakajairwa regimen yeadriamycin-ine musanganiswa chemotherapy, kenza yemazamu mune metastatic cancer cancer iyo. akundikana kusanganisa chemotherapy kana kudzokazve mukati memwedzi mitanhatu yeadjuvant chemotherapy, mutsara wekutanga kurapwa kweasiri diki kenza yemapapu, uye yechipiri-mutsara kurapwa kweAIDS murwere-inosanganisirwa carcinosarcoma.
2. Docetaxel: Kurapwa kwegomarara rezamu repamusoro kana kuti metastatic rakakundikana pamberi pechemotherapy;yekurapa kwepamusoro kana metastatic isiri-diki cell kenza yemapapu iyo yakundikana necisplatin-based chemotherapy.Inoshanda zvakare kune gastric cancer uye cancer yeprostate.
3. Liposomal paclitaxel: Inogona kushandiswa seyokutanga-mutsara chemotherapy yekenza yeovarian uye yekutanga-mutsara chemotherapy yekurapa ovarian metastatic cancer, uye inogonawo kushandiswa pamwe chete necisplatin.Inogona zvakare kushandiswa pakutevera kurapwa kwevarwere vegomarara rezamu avo vakarapwa neyakajairwa chemotherapy ine adriamycin kana kurapwa kwevarwere vanezve.Inogona zvakare kushandiswa musanganiswa ne cisplatin seyekutanga-mutsara chemotherapy kune varwere vasina diki-diki kenza yemapapu isingagone kurapwa nekuvhiyiwa kana radiotherapy.
4. Albumin-bound paclitaxel: inoratidzirwa kurapwa kwekenza yemazamu yemazamu iyo yakundikana kusanganiswa kwekemotherapy kana yekenza yemazamu iyo yadzoka zvakare mukati memwedzi mitanhatu mushure mekugadzirisa chemotherapy.Kunze kwekunge pane kliniki inopikisa, chemotherapy yapfuura inofanira kusanganisira anthracycline anticancer agent.
II.Kusiyana kwekuchengetedzwa kwezvinodhaka
1. Paclitaxel: kusagadzikana kwemvura.Kazhinji, jekiseni rinowedzera surfactants polyoxyethylene-inotsiva castor mafuta uye ethanol kuvandudza kunyungudika kwepaclitaxel mumvura, asi histamine inoburitswa kana polyoxyethylene-inotsiva castor oiri yakaderedzwa mu vivo, izvo zvinogona kutungamira kune zvakakomba allergic reaction uye zvinogona zvakare kuwedzera. iyo peripheral neurotoxicity ye paclitaxel, uye inogona zvakare kukanganisa kupararira kwemamorekuru ezvinodhaka kumatishu uye kukanganisa anti-tumor athari.
2. Docetaxel: kunyungudika kwemvura kwakaderera, uye inoda kugadziriswa nekuwedzera polysorbate 80 uye anhydrous ethanol, iyo yose inogona kuwedzera kuitika kwekuita kwakashata uye inogona kukonzera allergenic uye hemolytic reactions.
3. Liposomal paclitaxel: mushonga wacho wakavharidzirwa mu-lipid-se-bilayers kuti uite zviduku zviduku, uye mushonga wacho wakavharidzirwa mu liposomal particles pasina polyoxyethylene-inotsiva castor mafuta uye anhydrous ethanol, iyo inokonzera kusawirirana.Nekudaro, zvidzidzo zvakaratidza kuti mushonga wepaclitaxel pachawo unogona kukonzera hypersensitivity reaction, asi pamwero wakaderera uchienzaniswa nejekiseni repaclitaxel.Parizvino, paclitaxel liposomes ichiri kuda allergy pretreatment kurapwa isati yashandiswa.
4. Albumin-bound paclitaxel: A new paclitaxel albumin lyophilized agent inoshandisa human albumin semutakuri wezvinodhaka uye stabilizer, iyo isina co-solvent polyoxyethylene-inotsiva castor oil uye ine zvishoma paclitaxel content ine paclitaxel liposomes, uye haina zvinoda pretreatment usati warapwa.
Ongorora: Kugona kushanda nesimba uye mashandisirwo akafukidzwa mumharidzo iyi anotorwa mumabhuku akadhindwa.
Yunnan Hande Biotechnology Co., Ltd yanga iri nyanzvi mukugadzirwa kwepaclitaxel APIkweanopfuura makore makumi maviri, uye ndeimwe yepasi rose yakazvimiririra inogadzira paclitaxel API, inotorwa nechirimwa anti-cancer mushonga, yakatenderwa neUS FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan uye mamwe masangano anodzora nyika. .Hande inogona kupa kwete chete yepamusoro-mhandopaclitaxel mbishi zvinhu, asiwo tekinoroji yekusimudzira masevhisi ane hukama ne paclitaxel kuumbwa.Kuti uwane rumwe ruzivo, ndapota inzwa wakasununguka kutibata pa18187887160.
Nguva yekutumira: Zvita-08-2022