Kurara chinhu chakakosha chehupenyu hwezuva nezuva hwevanhu, hune simba rakakosha pahutano hwemunhu hwemuviri nepfungwa, kushanda kwemuviri uye kugona kwekuziva.Melatonin, hormone inobudiswa nepineal gland, inoita basa guru mukugadzirisa rhythm yekurara uye kuchengetedza mamiriro ekurara.Ichi chinyorwa chichaongorora kudzora mhedzisiro ye melatonin pakurara kubva pamaonero ezvinyorwa zvehunyanzvi.
Chimiro uye secretion musimboti we melatonin
Melatonin imhando yeindole hormone yakagadzirwa uye yakavanzwa nepituitary gland yemammalian pineal gland, ine rhythm iri pachena.Munharaunda ine chiedza chakakwana, retina inonzwa chiedza uye inhibits melatonin synthesis uye secretion kuburikidza ne retina-hypothalamic-pineal axis.Munzvimbo ine rima, retina hainzwe kureruka, uye inosimudzira synthesis uye secretion ye melatonin kuburikidza ne retina-hypothalamic-pineal axis.
Kukanganisa kwe melatonin pamhando yekurara
Melatonininokurudzira kurara zvakanyanya nekudyidzana neakananga melatonin receptors kudzora wachi yecircadian uye kumisa kumuka.Pakati pehusiku, mazinga emelatonin anokwira, zvichibatsira kugadzirisa wachi yemuviri uye kuita kuti munhu arare.Panguva imwecheteyo, melatonin inogonawo kubatsira kuchengetedza kurara nekudzvinyirira kumuka.Zvidzidzo zvakaratidza kuti kudzora mhedzisiro ye melatonin pakurara ine hukama zvakanyanya nedosi uye nguva yekutonga.
Tatu, melatonin kusagadzikana uye zvirwere zvine chekuita nekurara
Dysregulation ye melatonin inogona kukonzera kusagadzikana kwekurara uye zvimwe zvine chekuita nekurara.Semuenzaniso, matambudziko ekurara akadai sekushaya hope, shift syndrome, uye kuomerwa nekugadzirisa kune jet lag zvine chekuita nekukanganisika kwe melatonin secretion rhythm.Pamusoro pezvo, zvimwe zvidzidzo zvakaratidza kuti kusakwana kugadzirwa kwemelatonin kunogona kuwedzera njodzi yechirwere cheAlzheimer, kushushikana uye zvimwe zvirwere.
mhedziso
Basa re melatonin mukudzora kurara rakadzidzwa zvakanyanya pamatanho akawanda.Nekudaro, kunyangwe basa rakanyatsogadziriswa re melatonin mukudzora kurara, pachine mibvunzo yakawanda inoda kuongororwa zvakare.Semuenzaniso, iyo chaiyo nzira yekuita kwe melatonin ichiri kuda kuenderera mberi nekudzidza;Mhedzisiro ye melatonin pakuraira kwekurara inogona kunge yakasiyana muvanhu vakasiyana (sevanhu vane mazera akasiyana, murume kana murume uye nemararamiro).Uye ongorora kudyidzana pakati pemelatonin uye zvimwe zvehupenyu uye hwepfungwa hutano zvinhu.
Pamusoro pezvo, zvakakosha kucherechedza kuti kunyangwe kushandiswa kwemelatonin mukudzora kurara kuchiratidza tarisiro inovimbisa, kuchengetedzeka kwayo, kushanda nesimba uye kushandiswa kwakakwana kuchiri kuda humwe humbowo hwekiriniki.Naizvozvo, mafambiro ekutsvagisa emangwana anofanirwa kusanganisira kuitisa mimwe miedzo yekiriniki kuti vaone mhedzisiro ye melatonin mukuvandudza kurara uye kukanganiswa kwakabatana.
reference
Bachman,JG,&Pandi-Perumal,SR(2012) .Melatonin:makiriniki ekushandisa kupfuura matambudziko ekurara.Journal of pineal research,52(1),1-10.
Brayne,C.,&Smythe,J.(2005).Basa remelatonin mukurara uye kukosha kwayo kuchipatara.Journal of Pineal Research,39(3),
Nguva yekutumira: Sep-27-2023