Semi-synthetic paclitaxel mushonga unoshandiswa zvakanyanya mukurapa kenza, unoshandiswa zvakanyanya mukurapa magomarara akasiyana siyana nekuda kwekuita kwawo kunoshamisa uye kuderera kwehupfu mhedzisiro. Chinyorwa ichi chichasuma ruzivo rwehunyanzvi hwemaitiro ekuita, pharmacological chiito uye kuchipatara kushandiswa kwesemi-synthetic paclitaxelzvakadzama.
Nzira yekuita
The mechanism of action ofsemi-synthetic paclitaxelKunyanya kuburikidza nekudzivisa iyo polymerization yetubulin, kuparadza cell microtubule network, nekudaro inhibiting kupararira kwesero uye inducing cell apoptosis. Pamusoro pezvo, semi-synthetic paclitaxel inogona zvakare kudzora maitiro ekudzivirira emuviri webundu maseru uye kuwedzera anti-bundu kugona kwemuviri. .
Pharmacological madhara
Semi-synthetic paclitaxel yakaratidza zvinoshamisa kuita kwecancer mukuyedza kwemishonga, uye ine kurapa kwakanaka kune akasiyana kenza sekenza yemazamu, kenza yeovarian nekenza yemapapu.
Kudzivirirwa kwekuwedzera kwesero: semi-synthetic paclitaxel inogona kutadzisa kuwanda kwebundu masero, kunyanya kumasero ari mumitotic nhanho.
Induction yeapoptosis: semi-synthetic paclitaxel inogona kukonzeresa apoptosis yebundu maseru nekudzora iyo apoptosis mashandiro e tumor cell, kuitira kuti uwane chinangwa chekurapa bundu.
Wedzera mhinduro yekudzivirirwa kwemuviri: semi-synthetic paclitaxel inogona kudzora maitiro ekudzivirira ezvirwere zvebundu maseru uye kuwedzera anti-bundu kugona kwemuviri.
Clinical application
Semi-synthetic paclitaxel inoshandiswa zvakanyanya mukurapa kwekenza dzakasiyana siyana, senge kenza yemazamu, kenza yeovarian, kenza yemapapu uye zvichingodaro. dzakasiyana-siyana kenza.Mukushandiswa kwekiriniki, semi-synthetic paclitaxel inowanzoshandiswa pamwe chete nemamwe chemotherapeutic agents kuvandudza kushanda kwekurapa.
Toxic side effects
Iyo chepfu mhedzisiro ye semi-synthetic paclitaxel yakadzikira, asi inogona kuramba ichikonzeresa mamwe maitiro akashata, senge anaphylaxis, kudzvinyirirwa kwemwongo, huturu hwemoyo, zvichingodaro. zvinoenderana nemamiriro ezvinhu chaiwo omurwere uye kushivirira kwemushonga kuti uderedze kukonzeresa kwechepfu mhedzisiro kumurwere.
Tarisiro yebudiriro yeramangwana
Nekuenderera mberi kwekuenderera mberi kwesainzi uye tekinoroji uye nekudzika kwetsvagiridzo pa paclitaxel, tsvagiridzo yeramangwana pamusoro pe semi-synthetic paclitaxel ichave yakawedzera uye yakadzika. tsvakurudzo ichaitwa pamusoro pekugadzirisa kurapa kwe semi-synthetic paclitaxel uye kuderedza huturu hwayo. Panguva imwe chete, nekuvandudzwa kwemaitiro ekutanga akadai se genetic engineering uye cell therapy, nzira dzomunhu dzokurapa dze semi-synthetic paclitaxel. zvinogonekawo, zvichipa varwere vegomarara nzira dzekurapa dzakanyanya uye dzinoshanda.
Mhedziso
Semushonga wakakosha wekurwisa cancer,semi-synthetic paclitaxeline huwandu hwakawanda hwemakiriniki ekushandisa.Iyo yakakosha kurapa maitiro uye yakaderera muchetura mhedzisiro inoita kuti ive imwe yezvakakosha sarudzo dzekurapa kwekenza dzakawanda.Munguva yemberi, tsvakiridzo yesemi-synthetic paclitaxel ichave yakadzama uye. yakakwana, ichipa nzira dzekurapa dziri nani uye tariro yekupona kune varwere vegomarara.
Ongorora: Mabhenefiti angangodaro uye mashandisirwo anoratidzwa muchinyorwa chino anobva mumabhuku akaburitswa.
Nguva yekutumira: Nov-28-2023