Paclitaxel yakanakisa yakasikwa anti-cancer mushonga wawanikwa parizvino.Inoshandiswa zvakanyanya mukurapa kwegomarara reovarian,gomarara rezamu,kenza yemapapu,mumusoro nemutsipa tumors,gomarara resophageal,gomarara remudumbu uye nyoro nyoro sarcoma.Paclitaxelyakwezva kufarira kukuru kubva kumasaenzi nekuda kwechimiro chayo chakaomarara uye chitsva chemakemikari, nzira dzakasiyana dzekuita, inovimbika anticancer chiitiko, uye kushomeka kwakanyanya kwezviwanikwa. Maererano nehuwandu, anopfuura makumi matatu marabhoritari epamusoro pasi rose akaitwa mukutsvagisa kweTotal. synthesis ye paclitaxel, uye makwikwi anotyisa, ayo ave kutarisa kweorganic synthetic chemistry mukupera kwezana ramakore rechi20.
Iyo yakasarudzika anti-tumor meshini ye paclitaxel
Paclitaxel inogona kugadzira Tubulin neTubulin dimer inoumba mamicrotubules kurasikirwa neDynamic equilibrium, kukurudzira uye kukurudzira Tubulin polymerization, microtubule kusangana, uye kudzivirira depolymerization, kuitira kudzikamisa mamicrotubules uye kumisa Mitosis yekenza maseru uye kukonzeresa apoptosis, nekudaro kudzivirira zvinobudirira kuwanda kwegomarara. masero uye kutamba basa rekurwisa cancer.
Kutaura zvazviri, Tubulin, iyo ine hukama hwepedyo nesero Mitosis, inowanikwa pasi rose mumasero eukaryotic. Anogona polymerize kuita mamicrotubules nenzira inochinja.Kuparadzaniswa kweChromosome kunoda rubatsiro rwemamicrotubules aya.Mushure meMitosis, mamicrotubules aya anoiswazve muTubulin. Kuparara kwesando semamicrotubules kunogona kuuraya masero ane kupatsanurwa kusina kujairika. Mimwe mishonga inokosha inorwisa kenza, yakadai secolchicine, Vinblastine, Vincristine, inoita basa rekurwisa bundu nekudzivirira Tubulin kubva ku polymerization.
Kusiyana ne anti Mitosis uye anti-tumor zvinodhaka,paclitaxelndiwo mushonga wekutanga wakawanikwa unogona kupindirana neTubulin polymer, kureva kuti, inoshanda nekunyatso kusanganisa ne microtubules kuti iite kuti igadzikane.Panguva imwe chete, inowanikwa kuti paclitaxel inoratidza migumisiro yakanaka pamhando dzakasiyana-siyana dzakaoma tumor cell.Ichi chitsva. kuwanikwa kwakakwezva nyanzvi dzebiology dzakawanda kushandisapaclitaxelsechishandiso chekutsvagisa mubiomedicine, kuongorora nzvimbo dzisingazivikanwe dzesero chiitiko uye nekutsvaga nzira nyowani dzemishonga inorwisa cancer.
Tsanangudzo:Kugona kuita uye mashandisirwo ataurwa muchinyorwa chino zvese zvinobva mumabhuku anowanikwa pachena.
Yunnan Hande Bio-tech yanga yakatarisana nekugadzirwa kwepaclitaxel kwemakore makumi maviri nemasere.Ibhizimusi rekugadzira rakazvimirira repaclitaxel raw materials, iro rakatenderwa nemasangano anodzora nyika akadai seFDA muUnited States, EDQM muEurope, TGA muAustralia, CFDA muChina, India, neJapan.Yunnan Handepaclitaxelinowanikwa muzvitoro uye inotengeswa zvakananga nevagadziri.Kugamuchirwa kubvunza.
Nguva yekutumira: Jun-12-2023