Paclitaxel, chigadzirwa chechisikigo chakabviswa kubva mutsvuku fir, inhibits tumor cell mitosis nekuita pane microtubule proteins.Iyo yakajairwa mumiriri wekirasi yepaclitaxel uye ndiyo yekutanga makemikari mushonga kubva kuchirimwa chakasikwa kugamuchira FDA mvumo yekurapa kwakasiyana kenza, kusanganisira ovarian, zamu, mapapu, Kaposi's sarcoma, cervical uye pancreatic cancers.Mumakore achangopfuura,paclitaxelyakawanawo mukurumbira nokuda kwekushandiswa kwayo mumichina yezvokurapa.Ngatizvionei munyaya inotevera.
Zvishandiso zvepaclitaxelmumidziyo yekurapa
Paclitaxel, kuburikidza nepolymerization panguva imwe chete ne α (α-tubulin) uye β (β-tubulin) ye microtubulin, inokonzera nhamba yakawanda ye microtubules kuti iparadze zvisina kufanira, zvichiita kuti kuchinjwa kwehutano hwemasaga equilibrium mamiriro emasero uye kurasikirwa kwebasa rinowanzoitika, zvichiita kuti kukura kwesero kumire muG0 / G1 chikamu uye G1 uye GM chikamu, uye cell mitosis kuti idzivirirwe mu mitotic phase, pakupedzisira ibudirire kuvharidzirwa kwevascular smooth muscle division, kupararira Chigumisiro ndechekudzivisa kupatsanurwa uye kupararira kwevascular smooth muscle. uye kudzivirira restenosis kubva kuitika.
1. Paclitaxelmushonga stent
Drug-eluting stent (DES) is stent inoshandisa simbi isina chinhu stent chikuva kutakura (kutakura) anti-endothelial proliferation drug, iyo inoburitswa nekubuda kwenzvimbo mumudziyo kuti iite kuvharisa endothelial kuwanda kuitira kudzivirira restenosis mumhepo. stent.Kushandiswa kunobudirira kwezvinodhaka-eluting stents zvakanyanya kuderedza chiitiko chekudzorera uye kupindira zvakare, asi hazvina kuderedza chiyero chekurwara uye kufa.Pakanga pasina misiyano yakakosha muchiitiko chezviitiko zvekiriniki yekupedzisira pakati pezvinodhaka-eluting stents, paine mamwe echipiri ekupedzisira achibatsira.Zvinodhaka-eluting stents anosanganisira akashama stents akagadzirwa nesimbi isina tsvina kana cobalt-chromium ayo akafukidzwa neanorwisa proliferative zvinodhaka anotakura ane polymeric drug delivery coatings anosanganisira zvechigarire, biodegradable, uye polymer-isina zvinodhaka kuburitsa coating technologies, uye ine zvinodhaka zvinosanganisira limoxylates uye paclitaxel.Parizvino, paclitaxel drug stents inonyanya kushandiswa mukurapa zvirwere zvakasiyana-siyana zvecoronary, intracranial, carotid, renal uye femoral arteries.
2. Paclitaxel-drug-coated balloons
Drug-coated balloon (DCB), senzira nyowani uye yakura yekupindira, yakaratidza mune akati wandei miedzo yekiriniki yekubudirira kwayo uye kuchengetedzeka muISR, intracoronary stenosis maronda, midziyo midiki maronda, bifurcation maronda, nezvimwe.
Ongorora: Iko kugona kushanda uye mashandisirwo anotsanangurwa muchinyorwa chino anobva mumabhuku akaburitswa.
Kuwedzera kuverenga:Yunnan Hande Biotechnology Co., Ltd yanga yakatarisana nekugadzirwa kwepaclitaxel kwemakore makumi maviri nemasere.Ndiyo yekutanga yakazvimirira kugadzira pasi rose-yakagadzirwa anticancer drug paclitaxel iyo yakatenderwa neUS FDA, European EDQM, Australian TGA, China CFDA, India, Japan nemamwe masangano anodzora nyika.enterprise.Kana uchida kutengaPurogiramu inonzi Paclitaxel, ndapota taura nesu paIndaneti.
Nguva yekutumira: Oct-09-2022