Chii chinonzi albumin-bound paclitaxel?

Chii chinonzi albumin-bound paclitaxel?Albumin-bound paclitaxel (inowanzozivikanwa sealbumin paclitaxel, yakapfupikiswa seNab-P) inyowani paclitaxel nanoformulation, iyo inozivikanwa pasi rese seyakanyanya kugadzirwa paclitaxel.Inosanganisa endogenous albumin yemunhu ne paclitaxel mune isiri-covalent fomu uye mhedzisiro nanoparticles inokunda zvachose kusakosha kwepaclitaxel kusanyungudika mumvura, pasina kudiwa kwepolyoxyethylene castor oil kana Tween 80 seyakagadziriswa.Sezvo albumin iri endogenous yakasikwa chigadzirwa, ine zvakanakira kuve yakachengeteka, isiri-chepfu, isiri-immunogenic, biodegradable, uye biocompatible.

Sei albumin-bound paclitaxel iri yepamusoro-soro?

1. Kwete co-solubilizationno pre-kurapwa

Kutora mapuroteni eplasma echisikigo, anosunga hydrophobic paclitaxel mamorekuru mune isiri-covalent fomu isina chero co-solvent, ichibvisa iyo hypersensitivity uye chepfu maitiro anokonzerwa ne-co-solvents, nokudaro kubvisa kudiwa kwehomoni pretreatment isati yashandiswa uye kupfupisa iyo infusion nguva. kusvika kumaminitsi makumi matatu, kupfupisa zvakanyanya kugara muchipatara kwevarwere veoncology, uye kunyange kupedza chemotherapy kuburikidza nekiriniki yezuva.

2. Zviri nani pharmacokinetics

Kuenzaniswa neyakajairwa paclitaxel, albumin paclitaxel ine kukurumidza uye yakakwira kuparadzirwa kwetishu mumuviri, pamwe nekunonoka kubuda kubva mumatishu, iyo inoregererwa muyero mumuviri wemunhu inogona kuwedzera zvakanyanya uye mhedzisiro yekurapa inovandudzwa zvakanyanya.

3. Sarudzo yemunharaunda bundu aggregation

Chimwe chezvikonzero nei varwere vazhinji vachitya paclitaxel chemotherapy ndechekuti kugoverwa kwechinyakare paclitaxel mumatumbu emota uye mamwe akajairwa matishu zvakangofanana, zvichikonzera mhedzisiro yakawanda.Kusiyana neizvi, paclitaxel ine chishamiso che "selective local bundu kupfumisa" uye kusungirirwa kwayo mumabundu tishu kwakakwira zvakanyanya kupfuura kune mamwe matushu akajairwa.

Cherechedza: Izvo zvinogona kuitika uye mashandisirwo anotsanangurwa muchinyorwa chino anotorwa kubva kumabhuku akadhindwa.

Yunnan Hande Bio-Tech Co., Ltd yanga iri nyanzvi mukugadzirwa kwepaclitaxel APIkweanopfuura makore makumi maviri, uye ndeimwe yevanotungamira pasi rose vagadziri vepaclitaxel API nemvumo yeFDA, CEP chitupa uye GMP chitupa muChina.Hande inogona kupa kwete yemhando yepamusoro paclitaxel API chete asiwotekinoroji yekufambisa sevhisi ye paclitaxel albumin.Kuti uwane rumwe ruzivo, ndapota inzwa wakasununguka kutibata pa18187887160.