Nei Albumin-yakasungwa paclitaxel isingade kugadzirwa?

Parizvino, kune marudzi matatu ekugadzirira kwepaclitaxel pamusika kuChina, kusanganisira jekiseni repaclitaxel, Liposomal paclitaxel neAlbumin-bound paclitaxel. Majekiseni ese epaclitaxel neLiposomal paclitaxel ejekiseni anoda kurapwa nemishonga inokonzeresa allergy, asi nei Albumin- yakasungwa paclitaxel haidi kurapwa?Ngatitarisei zvinotevera.

Sei Albumin-bound paclitaxel isingade kugadzirwa

1.Paclitaxel jekiseni

Kuwedzera kunyungudika kwemvura kwepaclitaxel, mushonga wepaclitaxel jekiseni unoumbwa ne polyoxyethylene castor oil uye ethanol.Polyoxyethylene castor oil, as an allergenic, ine mamwe asiri-ionic block copolymers muchimiro chayo chemolecular, anogona kukurudzira muviri kuburitsa histamine. uye kukonzera allergic reaction.Pamberi pekushandiswa kwekiriniki, glucocorticoids uye antihistamines zvinofanira kushandiswa pakurapa.

2.Liposomal paclitaxel

Liposomal paclitaxel inonyanya phospholipid bimolecular liposomes ine dhayamita ye400 nm inoumbwa nelecithin uye cholesterol mune imwe proportion.Haina polyoxyethylene castor oil uye absolute ethanol inogona kukonzera allergy.

Zvakadaro, zvimwe zvidzidzo zvakaratidza kuti paclitaxel pachayo inogona kukonzera hypersensitivity, inova ine chekuita nekushandiswa kwemasophils, IgE uye IgG. inoda allergic pretreatment isati yashandiswa.

3.Albumin-bound paclitaxel

Albumin-bound paclitaxel, ine albumin yemunhu semutakuri, ine zvakanakira kuora zviri nyore mu vivo, kuwanda kwezvinodhaka mumamota, kunanga kwakasimba uye kushanda kwechemotherapy kwakakwira.

MuChikamu I, II kana III zvidzidzo zvealbumin-bound paclitaxel, kunyange zvazvo pasina pretreatment yakaitwa, hapana hypersensitivity reaction yakawanikwa. .Nekudaro, pretreatment before administration of albumin bound paclitaxel is not recommended at now.

Ongorora: Iko kugona kushanda uye mashandisirwo akaunzwa muchinyorwa ichi zvese zvinobva kumabhuku akadhindwa.

Yunnan Hande Biotechnology Co., Ltd yanga iri nyanzvi mukugadzirapaclitaxel APIkweanopfuura makore makumi maviri, uye ndeimwe yepasi rose yakazvimiririra inogadzira paclitaxel API, inotorwa nechirimwa anti-cancer drug, yakatenderwa neUS FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan nemamwe masangano anodzora nyika. .Hande inogona kupa kwete chete yepamusoro-soropaclitaxel mbishi zvinhu,asi zvakare tekinoroji yekusimudzira masevhisi ane chekuita ne paclitaxel formulation.Kuwana rumwe ruzivo, ndapota inzwa wakasununguka kutibata pa18187887160.